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The Y271 and I274 Amino Acids in Reverse Transcriptase of Human Immunodeficiency Virus-1 Are Critical to Protein Stability

Reverse transcriptase (RT) of human immunodeficiency virus (HIV)-1 plays a key role in initiating viral replication and is an important target for developing anti-HIV drugs. Our previous study showed that two mutations (Y271A and I274A) in the turn RT (Gln(269)-Arg(277)) abrogated viral replication,...

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Detalles Bibliográficos
Autores principales:	Zhang, Hao-Jie, Wang, Yong-Xiang, Wu, Hao, Jin, Dong-Yan, Wen, Yu-Mei, Zheng, Bo-Jian
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701634/ https://www.ncbi.nlm.nih.gov/pubmed/19578544 http://dx.doi.org/10.1371/journal.pone.0006108

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