Cargando…

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one α-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its morphogenetic properties, prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pervushin, Konstantin, Tan, Edward, Parthasarathy, Krupakar, Lin, Xin, Jiang, Feng Li, Yu, Dejie, Vararattanavech, Ardcharaporn, Soong, Tuck Wah, Liu, Ding Xiang, Torres, Jaume
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702000/ https://www.ncbi.nlm.nih.gov/pubmed/19593379 http://dx.doi.org/10.1371/journal.ppat.1000511

Ejemplares similares

Expression and purification of coronavirus envelope proteins using a modified β-barrel construct
por: Parthasarathy, Krupakar, et al.
Publicado: (2012)

Structural Flexibility of the Pentameric SARS Coronavirus Envelope Protein Ion Channel
por: Parthasarathy, Krupakar, et al.
Publicado: (2008)

Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein
por: Torres, Jaume, et al.
Publicado: (2007)

Two Different Conformations in Hepatitis C Virus p7 Protein Account for Proton Transport and Dye Release
por: Gan, Siok Wan, et al.
Publicado: (2014)

The Transmembrane Oligomers of Coronavirus Protein E
por: Torres, Jaume, et al.
Publicado: (2005)

Model of a Putative Pore: The Pentameric α-Helical Bundle of SARS Coronavirus E Protein in Lipid Bilayers
por: Torres, Jaume, et al.
Publicado: (2006)

Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system
por: Tan, Bao Zhen, et al.
Publicado: (2009)

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels
por: Surya, Wahyu, et al.
Publicado: (2015)

Ion Channels Formed by SARS Coronavirus Envelope Protein: Lipid Regulation of Conductance and Selectivity
por: Verdiá-Báguena, Carmina, et al.
Publicado: (2013)

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis
por: Nieto-Torres, Jose L., et al.
Publicado: (2014)

Understanding alternative splicing of Ca(v)1.2 calcium channels for a new approach towards individualized medicine
por: Liao, Ping, et al.
Publicado: (2010)

Susceptibility of SARS Coronavirus-2 infection in domestic and wild animals: a systematic review
por: Rao, Sudhanarayani S., et al.
Publicado: (2022)

Modest Ca(V)1.3(42)-selective inhibition by compound 8 is β-subunit dependent
por: Huang, Hua, et al.
Publicado: (2014)

Alternative Splicing of L-type Ca(V)1.2 Calcium Channels: Implications in Cardiovascular Diseases
por: Hu, Zhenyu, et al.
Publicado: (2017)

β subunits of voltage-gated calcium channels in cardiovascular diseases
por: Loh, Kelvin Wei Zhern, et al.
Publicado: (2023)

Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)β Subunits in Cardiac Hypertrophy
por: Hu, Zhenyu, et al.
Publicado: (2016)

Structural model of the SARS coronavirus E channel in LMPG micelles
por: Surya, Wahyu, et al.
Publicado: (2018)

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis
por: Li, Shumin, et al.
Publicado: (2020)

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins
por: Li, Yan, et al.
Publicado: (2014)

Calfacilitin is a calcium channel modulator essential for initiation of neural plate development
por: Papanayotou, Costis, et al.
Publicado: (2013)

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids
por: Verdiá-Báguena, Carmina, et al.
Publicado: (2012)

Oep23 forms an ion channel in the chloroplast outer envelope
por: Goetze, Tom Alexander, et al.
Publicado: (2015)

Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Ca(V)1.2 calcium channel
por: Navakkode, Sheeja, et al.
Publicado: (2022)

The Complex Proteolipidic Behavior of the SARS-CoV-2 Envelope Protein Channel: Weak Selectivity and Heterogeneous Oligomerization
por: Surya, Wahyu, et al.
Publicado: (2023)

Characterization of Ca(V)1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and Ca(V)1.2 exon 33 expressions in human heart failure
por: Wang, Juejin, et al.
Publicado: (2017)

Inferences of actinobacterial metabolites to combat Corona virus
por: Manikkam, Radhakrishnan, et al.
Publicado: (2022)

TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke
por: Chen, Bo, et al.
Publicado: (2019)

Oligomerization-Dependent Beta-Structure Formation in SARS-CoV-2 Envelope Protein
por: Surya, Wahyu, et al.
Publicado: (2022)

In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor
por: Dey, Debajit, et al.
Publicado: (2020)

SARS coronavirus E protein forms cation-selective ion channels
por: Wilson, Lauren, et al.
Publicado: (2004)

Nitric Oxide, Iron and Neurodegeneration
por: Liu, Chao, et al.
Publicado: (2019)

Coronavirus virulence genes with main focus on SARS-CoV envelope gene
por: DeDiego, Marta L., et al.
Publicado: (2014)

Electrophysiology of Viral Envelope Protein Ion Channels in Lipid Membranes Across Apertures in Polystyrene and Silicon
por: Chaplot, Nipun, et al.
Publicado: (2010)

Coronavirus Proteins as Ion Channels: Current and Potential Research
por: McClenaghan, Conor, et al.
Publicado: (2020)

Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation
por: Mei, Qingsong, et al.
Publicado: (2019)

Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels
por: Tang, Willcyn, et al.
Publicado: (2016)

Envelope glycoprotein interactions in coronavirus assembly
Publicado: (1995)

Coronavirus envelope protein: current knowledge
por: Schoeman, Dewald, et al.
Publicado: (2019)

Relevance of SARS-CoV E Protein Ion Channel Activity in Virus Pathogenesis
por: Verdiá Báguena, Carmina, et al.
Publicado: (2015)

Recent Progress in Studies of Arterivirus- and Coronavirus-Host Interactions
por: Zhong, Yanxin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sar9be1fligpnqa9v0su8301eg