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ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

Glutathionylspermidine is an intermediate formed in the biosynthesis of trypanothione, an essential metabolite in defence against chemical and oxidative stress in the Kinetoplastida. The kinetic mechanism for glutathionylspermidine synthetase (EC 6.3.1.8) from Crithidia fasciculata (CfGspS) obeys a...

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Detalles Bibliográficos
Autores principales:	Oza, Sandra L, Chen, Shoujun, Wyllie, Susan, Coward, James K, Fairlamb, Alan H
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2008
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702004/ https://www.ncbi.nlm.nih.gov/pubmed/18959765 http://dx.doi.org/10.1111/j.1742-4658.2008.06670.x

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