Significance of the Y-box proteins in human cancers

Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of...

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Detalles Bibliográficos
Autores principales: Matsumoto, Ken, Bay, Boon-Huat
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702063/
https://www.ncbi.nlm.nih.gov/pubmed/19565008
Descripción
Sumario:Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of Y-box protein 1 (YB-1), the most extensively studied of the Y-box protein in tumorigenesis, and its clinicopathological significance. YB-1 has the potential to be a prognostic marker and predictor of chemoresistance in human cancers.

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