Significance of the Y-box proteins in human cancers

Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of...

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Detalles Bibliográficos
Autores principales: Matsumoto, Ken, Bay, Boon-Huat
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702063/
https://www.ncbi.nlm.nih.gov/pubmed/19565008
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author Matsumoto, Ken
Bay, Boon-Huat
author_facet Matsumoto, Ken
Bay, Boon-Huat
author_sort Matsumoto, Ken
collection PubMed
description Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of Y-box protein 1 (YB-1), the most extensively studied of the Y-box protein in tumorigenesis, and its clinicopathological significance. YB-1 has the potential to be a prognostic marker and predictor of chemoresistance in human cancers.
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spelling pubmed-27020632009-06-29 Significance of the Y-box proteins in human cancers Matsumoto, Ken Bay, Boon-Huat J Mol Genet Med Mini-Review Y-box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control. Here, we give a brief overview of the structure, regulation and physiological functions of the Y-box proteins. This is followed by examining the role of Y-box protein 1 (YB-1), the most extensively studied of the Y-box protein in tumorigenesis, and its clinicopathological significance. YB-1 has the potential to be a prognostic marker and predictor of chemoresistance in human cancers. Library Publishing Media 2005-08-03 /pmc/articles/PMC2702063/ /pubmed/19565008 Text en © Copyright Matsumoto and Bay http://www.libpubmedia.co.uk/MedJ/LicenceForUsers.pdf This is an open access article, published under the terms of the Licence for Users available at http://www.libpubmedia.co.uk/MedJ/LicenceForUsers.pdf. This licence permits noncommercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.
spellingShingle Mini-Review
Matsumoto, Ken
Bay, Boon-Huat
Significance of the Y-box proteins in human cancers
title Significance of the Y-box proteins in human cancers
title_full Significance of the Y-box proteins in human cancers
title_fullStr Significance of the Y-box proteins in human cancers
title_full_unstemmed Significance of the Y-box proteins in human cancers
title_short Significance of the Y-box proteins in human cancers
title_sort significance of the y-box proteins in human cancers
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702063/
https://www.ncbi.nlm.nih.gov/pubmed/19565008
work_keys_str_mv AT matsumotoken significanceoftheyboxproteinsinhumancancers
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