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Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres

BACKGROUND: Human papillomavirus (HPV) L1 capsid proteins can self-assemble into pentamers (capsomeres) that are immunogenic and can elicit neutralizing antibodies. Structural modelling of L1 inter-pentameric interactions predicts that helix 4 (h4) of each of the five L1 monomers project laterally a...

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Detalles Bibliográficos
Autores principales:	Murata, Yoshihiko, Lightfoote, Paula M, Rose, Robert C, Walsh, Edward E
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702290/ https://www.ncbi.nlm.nih.gov/pubmed/19538743 http://dx.doi.org/10.1186/1743-422X-6-81

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