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The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study
BACKGROUND: Endothelial dysfunction is thought to be a potential mechanism for the decreased presence of coronary collaterals. The aim of the study was to investigate the association between systemic endothelial function and the extent of coronary collaterals. METHODS: We investigated the associatio...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702291/ https://www.ncbi.nlm.nih.gov/pubmed/19527494 http://dx.doi.org/10.1186/1476-7120-7-25 |
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author | Ozdemir, Aydan Ongun Gulec, Sadi Uslu, Nihal Kaya, Cansın Tulunay Ozdol, Cagdas Turhan, Sibel Atmaca, Yusuf Altin, Timucin Erol, Cetin |
author_facet | Ozdemir, Aydan Ongun Gulec, Sadi Uslu, Nihal Kaya, Cansın Tulunay Ozdol, Cagdas Turhan, Sibel Atmaca, Yusuf Altin, Timucin Erol, Cetin |
author_sort | Ozdemir, Aydan Ongun |
collection | PubMed |
description | BACKGROUND: Endothelial dysfunction is thought to be a potential mechanism for the decreased presence of coronary collaterals. The aim of the study was to investigate the association between systemic endothelial function and the extent of coronary collaterals. METHODS: We investigated the association between endothelial function assessed via flow mediated dilation (FMD) of the brachial artery following reactive hyperemia and the extent of coronary collaterals graded from 0 to 3 according to Rentrop classification in a cohort of 171 consecutive patients who had high grade coronary stenosis or occlusion on their angiograms. RESULTS: Mean age was 61 years and 75% were males. Of the 171 patients 88 (51%) had well developed collaterals (grades of 2 or 3) whereas 83 (49%) had impaired collateral development (grades of 0 or 1). Patients with poor collaterals were significantly more likely to have diabetes (p = 0.001), but less likely to have used statins (p = 0.083). FMD measurements were not significantly different among good and poor collateral groups (11.5 ± 5.6 vs. 10.4 ± 6.2% respectively, p = 0.214). Nitroglycerin mediated dilation was also similar (13.4 ± 5.9 vs. 12.8 ± 6.5%, p = 0.521). CONCLUSION: No significant association was found between the extent of angiographically visible coronary collaterals and systemic endothelial function assessed by FMD of the brachial artery. |
format | Text |
id | pubmed-2702291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27022912009-06-27 The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study Ozdemir, Aydan Ongun Gulec, Sadi Uslu, Nihal Kaya, Cansın Tulunay Ozdol, Cagdas Turhan, Sibel Atmaca, Yusuf Altin, Timucin Erol, Cetin Cardiovasc Ultrasound Research BACKGROUND: Endothelial dysfunction is thought to be a potential mechanism for the decreased presence of coronary collaterals. The aim of the study was to investigate the association between systemic endothelial function and the extent of coronary collaterals. METHODS: We investigated the association between endothelial function assessed via flow mediated dilation (FMD) of the brachial artery following reactive hyperemia and the extent of coronary collaterals graded from 0 to 3 according to Rentrop classification in a cohort of 171 consecutive patients who had high grade coronary stenosis or occlusion on their angiograms. RESULTS: Mean age was 61 years and 75% were males. Of the 171 patients 88 (51%) had well developed collaterals (grades of 2 or 3) whereas 83 (49%) had impaired collateral development (grades of 0 or 1). Patients with poor collaterals were significantly more likely to have diabetes (p = 0.001), but less likely to have used statins (p = 0.083). FMD measurements were not significantly different among good and poor collateral groups (11.5 ± 5.6 vs. 10.4 ± 6.2% respectively, p = 0.214). Nitroglycerin mediated dilation was also similar (13.4 ± 5.9 vs. 12.8 ± 6.5%, p = 0.521). CONCLUSION: No significant association was found between the extent of angiographically visible coronary collaterals and systemic endothelial function assessed by FMD of the brachial artery. BioMed Central 2009-06-15 /pmc/articles/PMC2702291/ /pubmed/19527494 http://dx.doi.org/10.1186/1476-7120-7-25 Text en Copyright © 2009 Ozdemir et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ozdemir, Aydan Ongun Gulec, Sadi Uslu, Nihal Kaya, Cansın Tulunay Ozdol, Cagdas Turhan, Sibel Atmaca, Yusuf Altin, Timucin Erol, Cetin The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title | The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title_full | The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title_fullStr | The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title_full_unstemmed | The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title_short | The relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
title_sort | relation between endothelial dependent flow mediated dilation of the brachial artery and coronary collateral development – a cross sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702291/ https://www.ncbi.nlm.nih.gov/pubmed/19527494 http://dx.doi.org/10.1186/1476-7120-7-25 |
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