Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

BACKGROUND: Tuberous sclerosis (TSC) is a hamartoma syndrome in which renal and lung tumors cause the greatest morbidity. Loss of either TSC1 or TSC2 in TSC hamartomas leads to activation of mTORC1 and suppression of AKT. Recent studies indicate that inhibition of mTORC1 with RAD001 (everolimus) lea...

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Detalles Bibliográficos
Autores principales: Pollizzi, Kristen, Malinowska-Kolodziej, Izabela, Stumm, Michael, Lane, Heidi, Kwiatkowski, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702302/
https://www.ncbi.nlm.nih.gov/pubmed/19527517
http://dx.doi.org/10.1186/1476-4598-8-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702302/
https://www.ncbi.nlm.nih.gov/pubmed/19527517
http://dx.doi.org/10.1186/1476-4598-8-38

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