Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen

BACKGROUND: Hepatitis C core protein is an attractive target for HCV vaccine aimed to exterminate HCV infected cells. However, although highly immunogenic in natural infection, core appears to have low immunogenicity in experimental settings. We aimed to design an HCV vaccine prototype based on core...

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Detalles Bibliográficos
Autores principales: Alekseeva, Ekaterina, Sominskaya, Irina, Skrastina, Dace, Egorova, Irina, Starodubova, Elizaveta, Kushners, Eriks, Mihailova, Marija, Petrakova, Natalia, Bruvere, Ruta, Kozlovskaya, Tatyana, Isaguliants, Maria, Pumpens, Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702340/
https://www.ncbi.nlm.nih.gov/pubmed/19505299
http://dx.doi.org/10.1186/1479-0556-7-7

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