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Of mice and humans: how good are HLA transgenic mice as a model of human immune responses?

BACKGROUND: Previous studies have defined vaccinia virus (VACV)-derived T cell epitopes in VACV-infected human leukocyte antigen-A*0201 (HLA-A2.1) transgenic (Tg) mice and A2.1-positive human Dryvax vaccinees. A total of 14 epitopes were detected in humans and 16 epitopes in A2.1 Tg mice; however, o...

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Detalles Bibliográficos
Autores principales:	Kotturi, Maya F, Assarsson, Erika, Peters, Bjoern, Grey, Howard, Oseroff, Carla, Pasquetto, Valerie, Sette, Alessandro
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702351/ https://www.ncbi.nlm.nih.gov/pubmed/19534819 http://dx.doi.org/10.1186/1745-7580-5-3

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