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Effect of a supplement rich in alkaline minerals on acid-base balance in humans
BACKGROUND: Western diets are considered acidogenic due to the high dietary acid load and a low intake of base-forming dietary minerals such as potassium, magnesium or calcium. In the present study we investigated the effect of a multimineral supplement (MMS) rich in alkaline minerals on acute and c...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702352/ https://www.ncbi.nlm.nih.gov/pubmed/19515242 http://dx.doi.org/10.1186/1475-2891-8-23 |
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author | König, Daniel Muser, Klaus Dickhuth, Hans-Hermann Berg, Aloys Deibert, Peter |
author_facet | König, Daniel Muser, Klaus Dickhuth, Hans-Hermann Berg, Aloys Deibert, Peter |
author_sort | König, Daniel |
collection | PubMed |
description | BACKGROUND: Western diets are considered acidogenic due to the high dietary acid load and a low intake of base-forming dietary minerals such as potassium, magnesium or calcium. In the present study we investigated the effect of a multimineral supplement (MMS) rich in alkaline minerals on acute and chronic regulation of acid-base balance with the pH of blood, urine and saliva as potential surrogate markers. METHODS: Parameters were measured (i) without MMS intake, (ii) in the three consecutive hours following ingestion (blood and urinary pH) and (iii) during one week with or without MMS intake (self-monitored using pH measurement strips). RESULTS: 25 (15 female; 10 male) subjects (age 44 ± 14 y; BMI 23.9 ± 1.9 kg/m(2)) were enrolled in the investigation. Following acute administration of the MMS in the morning, blood ph (1 and 2 h after ingestion) rose from 7.40 to 7.41; p < 0.05, and also urinary pH 3 h after ingestion (5.94 to 6.57; p < 0.05) increased significantly. Following longer-term supplementation, both the increase in urinary pH in the morning and in the evening occurred within 1 day. Compared to pH values without the MMS, average pH in urine was 11% higher in the morning and 5% higher in the evening. Analyses of food records showed that the increase in urinary pH was not related to dietary change. CONCLUSION: Our results suggest that the ingestion of a multimineral supplement is associated with both a significant increase in blood and urinary pH. The health related consequences of this supplementation remain to be determined. |
format | Text |
id | pubmed-2702352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27023522009-06-27 Effect of a supplement rich in alkaline minerals on acid-base balance in humans König, Daniel Muser, Klaus Dickhuth, Hans-Hermann Berg, Aloys Deibert, Peter Nutr J Research BACKGROUND: Western diets are considered acidogenic due to the high dietary acid load and a low intake of base-forming dietary minerals such as potassium, magnesium or calcium. In the present study we investigated the effect of a multimineral supplement (MMS) rich in alkaline minerals on acute and chronic regulation of acid-base balance with the pH of blood, urine and saliva as potential surrogate markers. METHODS: Parameters were measured (i) without MMS intake, (ii) in the three consecutive hours following ingestion (blood and urinary pH) and (iii) during one week with or without MMS intake (self-monitored using pH measurement strips). RESULTS: 25 (15 female; 10 male) subjects (age 44 ± 14 y; BMI 23.9 ± 1.9 kg/m(2)) were enrolled in the investigation. Following acute administration of the MMS in the morning, blood ph (1 and 2 h after ingestion) rose from 7.40 to 7.41; p < 0.05, and also urinary pH 3 h after ingestion (5.94 to 6.57; p < 0.05) increased significantly. Following longer-term supplementation, both the increase in urinary pH in the morning and in the evening occurred within 1 day. Compared to pH values without the MMS, average pH in urine was 11% higher in the morning and 5% higher in the evening. Analyses of food records showed that the increase in urinary pH was not related to dietary change. CONCLUSION: Our results suggest that the ingestion of a multimineral supplement is associated with both a significant increase in blood and urinary pH. The health related consequences of this supplementation remain to be determined. BioMed Central 2009-06-10 /pmc/articles/PMC2702352/ /pubmed/19515242 http://dx.doi.org/10.1186/1475-2891-8-23 Text en Copyright © 2009 König et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research König, Daniel Muser, Klaus Dickhuth, Hans-Hermann Berg, Aloys Deibert, Peter Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title | Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title_full | Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title_fullStr | Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title_full_unstemmed | Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title_short | Effect of a supplement rich in alkaline minerals on acid-base balance in humans |
title_sort | effect of a supplement rich in alkaline minerals on acid-base balance in humans |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702352/ https://www.ncbi.nlm.nih.gov/pubmed/19515242 http://dx.doi.org/10.1186/1475-2891-8-23 |
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