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Oocyte-Specific Deletion of Pten in Mice Reveals a Stage-Specific Function of PTEN/PI3K Signaling in Oocytes in Controlling Follicular Activation

Immature ovarian primordial follicles are essential for maintenance of the reproductive lifespan of female mammals. Recently, it was found that overactivation of the phosphatidylinositol 3-kinase (PI3K) signaling in oocytes of primordial follicles by an oocyte-specific deletion of Pten (phosphatase...

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Detalles Bibliográficos
Autores principales: Jagarlamudi, Krishna, Liu, Lian, Adhikari, Deepak, Reddy, Pradeep, Idahl, Annika, Ottander, Ulrika, Lundin, Eva, Liu, Kui
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702689/
https://www.ncbi.nlm.nih.gov/pubmed/19587782
http://dx.doi.org/10.1371/journal.pone.0006186