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Changes in cortical grey matter density associated with long-standing retinal visual field defects
Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts of the visual cortex. This could lead to degeneration of inactive cortical neuronal tissue, but this has not been established in humans. Here, we used magnetic...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702836/ https://www.ncbi.nlm.nih.gov/pubmed/19467992 http://dx.doi.org/10.1093/brain/awp119 |
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author | Boucard, Christine C. Hernowo, Aditya T. Maguire, R. Paul Jansonius, Nomdo M. Roerdink, Jos B. T. M. Hooymans, Johanna M. M. Cornelissen, Frans W. |
author_facet | Boucard, Christine C. Hernowo, Aditya T. Maguire, R. Paul Jansonius, Nomdo M. Roerdink, Jos B. T. M. Hooymans, Johanna M. M. Cornelissen, Frans W. |
author_sort | Boucard, Christine C. |
collection | PubMed |
description | Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts of the visual cortex. This could lead to degeneration of inactive cortical neuronal tissue, but this has not been established in humans. Here, we used magnetic resonance imaging to assess the effects of prolonged sensory deprivation in human visual cortex. High-resolution anatomical magnetic resonance images were obtained in subjects with foveal (age-related macular degeneration) and peripheral (glaucoma) retinal lesions as well as age-matched controls. Comparison of grey matter between patient and control groups revealed density reductions in the approximate retinal lesion projection zones in visual cortex. This indicates that long-term cortical deprivation, due to retinal lesions acquired later in life, is associated with retinotopic-specific neuronal degeneration of visual cortex. Such degeneration could interfere with therapeutic strategies such as the future application of artificial retinal implants to overcome lesion-induced visual impairment. |
format | Text |
id | pubmed-2702836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-27028362009-06-30 Changes in cortical grey matter density associated with long-standing retinal visual field defects Boucard, Christine C. Hernowo, Aditya T. Maguire, R. Paul Jansonius, Nomdo M. Roerdink, Jos B. T. M. Hooymans, Johanna M. M. Cornelissen, Frans W. Brain Original Articles Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts of the visual cortex. This could lead to degeneration of inactive cortical neuronal tissue, but this has not been established in humans. Here, we used magnetic resonance imaging to assess the effects of prolonged sensory deprivation in human visual cortex. High-resolution anatomical magnetic resonance images were obtained in subjects with foveal (age-related macular degeneration) and peripheral (glaucoma) retinal lesions as well as age-matched controls. Comparison of grey matter between patient and control groups revealed density reductions in the approximate retinal lesion projection zones in visual cortex. This indicates that long-term cortical deprivation, due to retinal lesions acquired later in life, is associated with retinotopic-specific neuronal degeneration of visual cortex. Such degeneration could interfere with therapeutic strategies such as the future application of artificial retinal implants to overcome lesion-induced visual impairment. Oxford University Press 2009-07 2009-05-25 /pmc/articles/PMC2702836/ /pubmed/19467992 http://dx.doi.org/10.1093/brain/awp119 Text en © 2009 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Boucard, Christine C. Hernowo, Aditya T. Maguire, R. Paul Jansonius, Nomdo M. Roerdink, Jos B. T. M. Hooymans, Johanna M. M. Cornelissen, Frans W. Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title | Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title_full | Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title_fullStr | Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title_full_unstemmed | Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title_short | Changes in cortical grey matter density associated with long-standing retinal visual field defects |
title_sort | changes in cortical grey matter density associated with long-standing retinal visual field defects |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702836/ https://www.ncbi.nlm.nih.gov/pubmed/19467992 http://dx.doi.org/10.1093/brain/awp119 |
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