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A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia

Limited behavioural repertoire impacts quality of life in chronic schizophrenia. We have previously shown that the amount of movement exhibited by patients with schizophrenia is positively correlated with the volume of left anterior cingulate cortex and that this quantity of movement can be increase...

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Autores principales: Farrow, Tom F.D, Hunter, Michael D, Wilkinson, Iain D, Spence, Sean A
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703198/
https://www.ncbi.nlm.nih.gov/pubmed/19572020
http://dx.doi.org/10.2174/1874440000903010048
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author Farrow, Tom F.D
Hunter, Michael D
Wilkinson, Iain D
Spence, Sean A
author_facet Farrow, Tom F.D
Hunter, Michael D
Wilkinson, Iain D
Spence, Sean A
author_sort Farrow, Tom F.D
collection PubMed
description Limited behavioural repertoire impacts quality of life in chronic schizophrenia. We have previously shown that the amount of movement exhibited by patients with schizophrenia is positively correlated with the volume of left anterior cingulate cortex and that this quantity of movement can be increased by modafinil. However, increased movement in itself may be of limited clinical significance. Hence, we sought to analyse the ‘structure’ of spontaneous movement in patients with schizophrenia and to examine whether the chunking of spontaneous activity has a neuroanatomical basis. ‘Actiwatches’ were used to record spontaneous motor activity over a 20 hour period in sixteen male patients with schizophrenia. Time-series data were analysed for the number of discrete spontaneous activities, which might indicate a degree of structure to ongoing activity. Subjects underwent a whole-brain structural MRI scan. The ‘number of discrete movement epochs’ correlated with volumes of regions within bilateral rostro-ventral putamen and temporal poles. These data suggest that in people with schizophrenia the volume of bilateral putamen may influence the complexity of their behaviours, as distinct from the overall amount of behaviour. The results are presented in the context of a large body of previous research examining the role of the basal ganglia in motor and cognitive pattern generation.
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spelling pubmed-27031982009-07-01 A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia Farrow, Tom F.D Hunter, Michael D Wilkinson, Iain D Spence, Sean A Open Neuroimag J Article Limited behavioural repertoire impacts quality of life in chronic schizophrenia. We have previously shown that the amount of movement exhibited by patients with schizophrenia is positively correlated with the volume of left anterior cingulate cortex and that this quantity of movement can be increased by modafinil. However, increased movement in itself may be of limited clinical significance. Hence, we sought to analyse the ‘structure’ of spontaneous movement in patients with schizophrenia and to examine whether the chunking of spontaneous activity has a neuroanatomical basis. ‘Actiwatches’ were used to record spontaneous motor activity over a 20 hour period in sixteen male patients with schizophrenia. Time-series data were analysed for the number of discrete spontaneous activities, which might indicate a degree of structure to ongoing activity. Subjects underwent a whole-brain structural MRI scan. The ‘number of discrete movement epochs’ correlated with volumes of regions within bilateral rostro-ventral putamen and temporal poles. These data suggest that in people with schizophrenia the volume of bilateral putamen may influence the complexity of their behaviours, as distinct from the overall amount of behaviour. The results are presented in the context of a large body of previous research examining the role of the basal ganglia in motor and cognitive pattern generation. Bentham Open 2009-06-09 /pmc/articles/PMC2703198/ /pubmed/19572020 http://dx.doi.org/10.2174/1874440000903010048 Text en © Farrow et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Farrow, Tom F.D
Hunter, Michael D
Wilkinson, Iain D
Spence, Sean A
A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title_full A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title_fullStr A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title_full_unstemmed A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title_short A Neuroanatomical Basis for the Frequency of Discrete Spontaneous Activities in Schizophrenia
title_sort neuroanatomical basis for the frequency of discrete spontaneous activities in schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703198/
https://www.ncbi.nlm.nih.gov/pubmed/19572020
http://dx.doi.org/10.2174/1874440000903010048
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