High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma

We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cel...

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Detalles Bibliográficos
Autores principales: Ziske, Carsten, Mezger, Jörg, Jiménez, Carlos, Kleinschmidt, Rolf, Pels, Hendrik, Schlegel, Uwe, Schmidt-Wolf, Ingo G.H.
Formato: Texto
Lenguaje:English
Publicado: German Medical Science 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703232/
https://www.ncbi.nlm.nih.gov/pubmed/19675701
Descripción
Sumario:We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died.

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