High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma

We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cel...

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Autores principales: Ziske, Carsten, Mezger, Jörg, Jiménez, Carlos, Kleinschmidt, Rolf, Pels, Hendrik, Schlegel, Uwe, Schmidt-Wolf, Ingo G.H.
Formato: Texto
Lenguaje:English
Publicado: German Medical Science 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703232/
https://www.ncbi.nlm.nih.gov/pubmed/19675701
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author Ziske, Carsten
Mezger, Jörg
Jiménez, Carlos
Kleinschmidt, Rolf
Pels, Hendrik
Schlegel, Uwe
Schmidt-Wolf, Ingo G.H.
author_facet Ziske, Carsten
Mezger, Jörg
Jiménez, Carlos
Kleinschmidt, Rolf
Pels, Hendrik
Schlegel, Uwe
Schmidt-Wolf, Ingo G.H.
author_sort Ziske, Carsten
collection PubMed
description We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died.
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spelling pubmed-27032322009-07-28 High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma Ziske, Carsten Mezger, Jörg Jiménez, Carlos Kleinschmidt, Rolf Pels, Hendrik Schlegel, Uwe Schmidt-Wolf, Ingo G.H. Ger Med Sci Article We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died. German Medical Science 2003-07-01 /pmc/articles/PMC2703232/ /pubmed/19675701 Text en Copyright © 2003 Ziske et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Article
Ziske, Carsten
Mezger, Jörg
Jiménez, Carlos
Kleinschmidt, Rolf
Pels, Hendrik
Schlegel, Uwe
Schmidt-Wolf, Ingo G.H.
High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title_full High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title_fullStr High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title_full_unstemmed High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title_short High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma
title_sort high-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary afp-producing intracranial germinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703232/
https://www.ncbi.nlm.nih.gov/pubmed/19675701
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