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Characteristics of Glottic Closure Reflex in a Canine Model

PURPOSE: The most important function of the larynx is airway protection which is provided through a polysynaptic reflex closure triggered by the receptors in the glottic and supraglottic mucosa, evoking the reflex contraction of the laryngeal muscles especially by strong adduction of vocal cords. Ba...

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Detalles Bibliográficos
Autores principales: Kim, Young-Ho, Kang, Ju Wan, Kim, Kwang-Moon
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703761/
https://www.ncbi.nlm.nih.gov/pubmed/19568600
http://dx.doi.org/10.3349/ymj.2009.50.3.380
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author Kim, Young-Ho
Kang, Ju Wan
Kim, Kwang-Moon
author_facet Kim, Young-Ho
Kang, Ju Wan
Kim, Kwang-Moon
author_sort Kim, Young-Ho
collection PubMed
description PURPOSE: The most important function of the larynx is airway protection which is provided through a polysynaptic reflex closure triggered by the receptors in the glottic and supraglottic mucosa, evoking the reflex contraction of the laryngeal muscles especially by strong adduction of vocal cords. Based on the hypotheses that central facilitation is essential for this bilateral adductor reflex and that its disturbance can result in weakened laryngeal closure, we designed this study to elucidate the effect of central facilitation on this protective reflex. MATERIALS AND METHODS: Seven adult, 20 kg mongrel dogs underwent evoked response laryngeal electromyography under 0.5 to 1.0 MAC (minimum alveolar concentration) isoflurane anesthesia. The internal branch of the superior laryngeal nerve was stimulated through bipolar platinum-iridium electrodes, and recording electrodes were positioned in the ipsilateral and contralateral thyroarytenoid muscles. RESULTS: Ipsilateral reflex closure was consistantly recorded regardless of anesthetic levels. However, contralateral reflex responses disappeared as anesthetic levels were deepened. Additionally, late responses (R2) were detected in one animal at lower level of anesthesia. CONCLUSIONS: Deepened level of anesthesia affects central facilitation and results in the loss of the crossed adductor reflex, predisposing to a weakened glottic closure response. Precise understanding of this effect may possibly provide a way to prevent aspiration in unconscious patients.
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spelling pubmed-27037612009-06-30 Characteristics of Glottic Closure Reflex in a Canine Model Kim, Young-Ho Kang, Ju Wan Kim, Kwang-Moon Yonsei Med J Original Article PURPOSE: The most important function of the larynx is airway protection which is provided through a polysynaptic reflex closure triggered by the receptors in the glottic and supraglottic mucosa, evoking the reflex contraction of the laryngeal muscles especially by strong adduction of vocal cords. Based on the hypotheses that central facilitation is essential for this bilateral adductor reflex and that its disturbance can result in weakened laryngeal closure, we designed this study to elucidate the effect of central facilitation on this protective reflex. MATERIALS AND METHODS: Seven adult, 20 kg mongrel dogs underwent evoked response laryngeal electromyography under 0.5 to 1.0 MAC (minimum alveolar concentration) isoflurane anesthesia. The internal branch of the superior laryngeal nerve was stimulated through bipolar platinum-iridium electrodes, and recording electrodes were positioned in the ipsilateral and contralateral thyroarytenoid muscles. RESULTS: Ipsilateral reflex closure was consistantly recorded regardless of anesthetic levels. However, contralateral reflex responses disappeared as anesthetic levels were deepened. Additionally, late responses (R2) were detected in one animal at lower level of anesthesia. CONCLUSIONS: Deepened level of anesthesia affects central facilitation and results in the loss of the crossed adductor reflex, predisposing to a weakened glottic closure response. Precise understanding of this effect may possibly provide a way to prevent aspiration in unconscious patients. Yonsei University College of Medicine 2009-06-30 2009-06-23 /pmc/articles/PMC2703761/ /pubmed/19568600 http://dx.doi.org/10.3349/ymj.2009.50.3.380 Text en © Copyright: Yonsei University College of Medicine 2009 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Young-Ho
Kang, Ju Wan
Kim, Kwang-Moon
Characteristics of Glottic Closure Reflex in a Canine Model
title Characteristics of Glottic Closure Reflex in a Canine Model
title_full Characteristics of Glottic Closure Reflex in a Canine Model
title_fullStr Characteristics of Glottic Closure Reflex in a Canine Model
title_full_unstemmed Characteristics of Glottic Closure Reflex in a Canine Model
title_short Characteristics of Glottic Closure Reflex in a Canine Model
title_sort characteristics of glottic closure reflex in a canine model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703761/
https://www.ncbi.nlm.nih.gov/pubmed/19568600
http://dx.doi.org/10.3349/ymj.2009.50.3.380
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