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Induction of Thyroid Gene Expression and Radioiodine Uptake in Melanoma Cells: Novel Therapeutic Implications

Both the MAP kinase and PI3K/Akt pathways play an important role in the pathogenesis of melanoma. We conducted the present study to test the hypothesis that targeting the two pathways to potently induce cell inhibition accompanied with thyroid iodide-handling gene expression for adjunct radioiodine...

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Detalles Bibliográficos
Autores principales: Hou, Peng, Liu, Dingxie, Ji, Meiju, Liu, Zhi, Engles, James M., Wahl, Richard L., Xing, Mingzhao
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703805/
https://www.ncbi.nlm.nih.gov/pubmed/19593429
http://dx.doi.org/10.1371/journal.pone.0006200