Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis

The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing. Here we show that high arginase activity, a hallmark of nonhealing disease, is p...

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Detalles Bibliográficos
Autores principales: Modolell, Manuel, Choi, Beak-San, Ryan, Robert O., Hancock, Maggie, Titus, Richard G., Abebe, Tamrat, Hailu, Asrat, Müller, Ingrid, Rogers, Matthew E., Bangham, Charles R. M., Munder, Markus, Kropf, Pascale
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703824/
https://www.ncbi.nlm.nih.gov/pubmed/19597544
http://dx.doi.org/10.1371/journal.pntd.0000480

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