Cargando…

IC(50)-to-K(i): a web-based tool for converting IC(50) to K(i) values for inhibitors of enzyme activity and ligand binding

A new web-server tool estimates K(i) values from experimentally determined IC(50) values for inhibitors of enzymes and of binding reactions between macromolecules (e.g. proteins, polynucleic acids) and ligands. This converter was developed to enable end users to help gauge the quality of the underly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cer, R. Z., Mudunuri, U., Stephens, R., Lebeda, F. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703898/ https://www.ncbi.nlm.nih.gov/pubmed/19395593 http://dx.doi.org/10.1093/nar/gkp253

Ejemplares similares

Comparison of Quantitative and Qualitative (Q)SAR Models Created for the Prediction of K(i) and IC(50) Values of Antitarget Inhibitors
por: Lagunin, Alexey A., et al.
Publicado: (2018)

Variations in IC(50) Values with Purity of Mushroom Tyrosinase
por: Neeley, Elizabeth, et al.
Publicado: (2009)

Proteochemometric Method for pIC50 Prediction of Flaviviridae
por: Singh, Divye, et al.
Publicado: (2022)

Comparability of Mixed IC(50) Data – A Statistical Analysis
por: Kalliokoski, Tuomo, et al.
Publicado: (2013)

An Experimental Study of the Relation between Mode I Fracture Toughness, K(Ic), and Critical Energy Release Rate, G(Ic)
por: Qiao, Yang, et al.
Publicado: (2023)

Gene-signature-derived IC(50)s/EC(50)s reflect the potency of causative upstream targets and downstream phenotypes
por: Renner, Steffen, et al.
Publicado: (2020)

Beyond IC(50)s: Towards Robust Statistical Methods for in vitro Association Studies
por: Beam, Andrew, et al.
Publicado: (2014)

A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)
por: Zhang, Hui, et al.
Publicado: (2013)

When Does the IC(50) Accurately Assess the Blocking Potency of a Drug?
por: Gomis-Tena, Julio, et al.
Publicado: (2020)

Terpenes Increase the Lipid Dynamics in the Leishmania Plasma Membrane at Concentrations Similar to Their IC(50) Values
por: Camargos, Heverton Silva, et al.
Publicado: (2014)

On Approximating the pIC(50) Value of COVID-19 Medicines In Silico with Artificial Neural Networks
por: Baressi Šegota, Sandi, et al.
Publicado: (2023)

Cutoff value of IC(50) for drug sensitivity in patient-derived tumor organoids in colorectal cancer
por: Tang, Yuting, et al.
Publicado: (2023)

Predicting the DPP-IV Inhibitory Activity pIC(50) Based on Their Physicochemical Properties
por: Gu, Tianhong, et al.
Publicado: (2013)

The Response of Tissue Mast Cells to TLR3 Ligand Poly(I:C) Treatment
por: Witczak, Piotr, et al.
Publicado: (2020)

Experimental ion mobility measurements in pure iC$_4$H$_{10}$10 and Ar-iC$_4$H$_{10}$ mixtures
por: Cortez, A F V, et al.
Publicado: (2019)

IC(50): an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
por: Xu, Yipeng, et al.
Publicado: (2022)

Effect of Inducers, Incubation Time and Heme Concentration on IC(50) Value Variation in Anti-heme Crystallization Assay
por: Nhien, Nguyen Thanh Thuy, et al.
Publicado: (2011)

Immunotherapeutic effects of intratumoral nanoplexed poly I:C
por: Aznar, M. Angela, et al.
Publicado: (2019)

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction
por: Lee, Yeeun, et al.
Publicado: (2021)

Corrigendum: IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
Publicado: (2023)

Specification of a 50 kW switched mode power converter
por: Vôlker, F
Publicado: (1995)

Exploiting poly(I:C) to induce cancer cell apoptosis
por: Bianchi, Francesca, et al.
Publicado: (2017)

IC Reference
por: Dolmazon, Emeline
Publicado: (2019)

A novel application of t-statistics to objectively assess the quality of IC(50) fits for P-glycoprotein and other transporters
por: O'Connor, Michael, et al.
Publicado: (2015)

IC(50) Evaluation of Platinum Nanocatalysts for Cancer Treatment in Fibroblast, HeLa, and DU-145 Cell Lines
por: González-Larraza, Pamela G., et al.
Publicado: (2020)

Numerical learning of deep features from drug-exposed cell images to calculate IC50 without staining
por: Cho, Kookrae, et al.
Publicado: (2022)

Classification of drug molecules considering their IC(50 )values using mixed-integer linear programming based hyper-boxes method
por: Armutlu, Pelin, et al.
Publicado: (2008)

ATI-2307 Exhibits Equivalent Antifungal Activity in Cryptococcus neoformans Clinical Isolates With High and Low Fluconazole IC(50)
por: Gerlach, Elliot S., et al.
Publicado: (2021)

The changing 50% inhibitory concentration (IC(50)) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer
por: He, Yifeng, et al.
Publicado: (2016)

CMOS IC Layout: Concepts, Methodologies, and Tools
por: Clein, Dan
Publicado: (1999)

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
por: Fernández, Francisco J., et al.
Publicado: (2022)

Ioh. Angelij Werdenhagen I.C. De rebuspublicis, Hanseaticis : Tractatus generalis
por: Werdenhagen, Johann angelius von, 1581-1652
Publicado: (1631)

The Relationship between the IC(50) Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition
por: Garcia-Molina, Pablo, et al.
Publicado: (2022)

A Deep Learning Model for Cell Growth Inhibition IC50 Prediction and Its Application for Gastric Cancer Patients
por: Joo, Minjae, et al.
Publicado: (2019)

Control of Interferon Production in Rabbit Cells Treated with Poly I:C
por: Armstrong, John A.
Publicado: (1970)

Pathological Role of Interleukin-17 in Poly I:C-Induced Hepatitis
por: He, Jianqin, et al.
Publicado: (2013)

Towards a Mechanism for Poly(I·C) Antiviral Priming in Oysters
por: Martins, Nelson E.
Publicado: (2020)

Development and Evaluation of a Barley 50k iSelect SNP Array
por: Bayer, Micha M., et al.
Publicado: (2017)

CMOS IC layout : concepts, methodologies, and tools /
por: Clein, Dan, 1958-
Publicado: (2000)

I.C.S. reference library : a series of textbooks prepared for the students of the International Correspondence Schools, and containing in permanent form the instruction papers, examination questions, and keys used in their various courses ...
Publicado: (1904)

Cannot write session to /tmp/vufind_sessions/sess_a7j25uvhrgcmel7mblqsf5t3bl