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Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

BACKGROUND: P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damag...

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Detalles Bibliográficos
Autores principales:	Solozobova, Valeriya, Rolletschek, Alexandra, Blattner, Christine
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704172/ https://www.ncbi.nlm.nih.gov/pubmed/19534768 http://dx.doi.org/10.1186/1471-2121-10-46

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