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RhoA-ROCK signaling is involved in contraction-mediated inhibition of SERCA2a expression in cardiomyocytes

In neonatal ventricular cardiomyocytes (NVCM), decreased contractile activity stimulates sarco-endoplasmic reticulum Ca(2+)-ATPase2a (SERCA2a), analogous to reduced myocardial load in vivo. This study investigated in contracting NVCM the role of load-dependent RhoA-ROCK signaling in SERCA2a regulati...

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Detalles Bibliográficos
Autores principales:	Vlasblom, Ronald, Muller, Alice, Beckers, Cora M. L., van Nieuw Amerongen, Geerten P., Zuidwijk, Marian J., van Hardeveld, Cornelis, Paulus, Walter J., Simonides, Warner S.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Signaling and Cell Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704291/ https://www.ncbi.nlm.nih.gov/pubmed/19294414 http://dx.doi.org/10.1007/s00424-009-0659-x

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