A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545

(11)C-labeled carbamates can be obtained in a three-component coupling reaction of primary or secondary amines with CO(2) and (11)C-methylation reagents. [(11)C]Methyl-triflate mediated methylation of carbamino adducts provides the corresponding (11)C-labeled carbamate groups in excellent yields und...

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Autores principales: Schoultz, B.W, Årstad, E, Marton, J, Willoch, F, Drzezga, A, Wester, H.-J, Henriksen, G
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704583/
https://www.ncbi.nlm.nih.gov/pubmed/19662146
http://dx.doi.org/10.2174/1874104500802010072
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author Schoultz, B.W
Årstad, E
Marton, J
Willoch, F
Drzezga, A
Wester, H.-J
Henriksen, G
author_facet Schoultz, B.W
Årstad, E
Marton, J
Willoch, F
Drzezga, A
Wester, H.-J
Henriksen, G
author_sort Schoultz, B.W
collection PubMed
description (11)C-labeled carbamates can be obtained in a three-component coupling reaction of primary or secondary amines with CO(2) and (11)C-methylation reagents. [(11)C]Methyl-triflate mediated methylation of carbamino adducts provides the corresponding (11)C-labeled carbamate groups in excellent yields under mild conditions (temperatures ≤ 40°C, 2 min reaction time). The utility of the method has been demonstrated by a highly efficient radiosynthesis of [(11)C]GR103545.
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spelling pubmed-27045832009-08-06 A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545 Schoultz, B.W Årstad, E Marton, J Willoch, F Drzezga, A Wester, H.-J Henriksen, G Open Med Chem J Article (11)C-labeled carbamates can be obtained in a three-component coupling reaction of primary or secondary amines with CO(2) and (11)C-methylation reagents. [(11)C]Methyl-triflate mediated methylation of carbamino adducts provides the corresponding (11)C-labeled carbamate groups in excellent yields under mild conditions (temperatures ≤ 40°C, 2 min reaction time). The utility of the method has been demonstrated by a highly efficient radiosynthesis of [(11)C]GR103545. Bentham Open 2008-07-16 /pmc/articles/PMC2704583/ /pubmed/19662146 http://dx.doi.org/10.2174/1874104500802010072 Text en © Schoultz et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Schoultz, B.W
Årstad, E
Marton, J
Willoch, F
Drzezga, A
Wester, H.-J
Henriksen, G
A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title_full A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title_fullStr A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title_full_unstemmed A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title_short A New Method for Radiosynthesis of (11)C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [(11)C]GR103545
title_sort new method for radiosynthesis of (11)c-labeled carbamate groups and its application for a highly efficient synthesis of the kappa-opioid receptor tracer [(11)c]gr103545
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704583/
https://www.ncbi.nlm.nih.gov/pubmed/19662146
http://dx.doi.org/10.2174/1874104500802010072
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