Mutant Glycyl-tRNA Synthetase (Gars) Ameliorates SOD1(G93A) Motor Neuron Degeneration Phenotype but Has Little Affect on Loa Dynein Heavy Chain Mutant Mice

BACKGROUND: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal muscular atrophy. GARS is ubiquitously expressed a...

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Detalles Bibliográficos
Autores principales: Banks, Gareth T., Bros-Facer, Virginie, Williams, Hazel P., Chia, Ruth, Achilli, Francesca, Bryson, J. Barney, Greensmith, Linda, Fisher, Elizabeth M. C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704870/
https://www.ncbi.nlm.nih.gov/pubmed/19593442
http://dx.doi.org/10.1371/journal.pone.0006218

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