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Surgical Resection of Lung Metastases: Results from 529 Patients
OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were adm...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705143/ https://www.ncbi.nlm.nih.gov/pubmed/19578657 http://dx.doi.org/10.1590/S1807-59322009000600008 |
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author | Younes, Riad N. Gross, Jefferson L. Taira, Andrea M. Martins, Andrea Aparecida C. Neves, Giuliana Sigolo |
author_facet | Younes, Riad N. Gross, Jefferson L. Taira, Andrea M. Martins, Andrea Aparecida C. Neves, Giuliana Sigolo |
author_sort | Younes, Riad N. |
collection | PubMed |
description | OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0–192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninety-month overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection. |
format | Text |
id | pubmed-2705143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-27051432009-07-06 Surgical Resection of Lung Metastases: Results from 529 Patients Younes, Riad N. Gross, Jefferson L. Taira, Andrea M. Martins, Andrea Aparecida C. Neves, Giuliana Sigolo Clinics (Sao Paulo) Clinical Science OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0–192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninety-month overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009-06 /pmc/articles/PMC2705143/ /pubmed/19578657 http://dx.doi.org/10.1590/S1807-59322009000600008 Text en Copyright © 2009 Hospital das Clínicas da FMUSP |
spellingShingle | Clinical Science Younes, Riad N. Gross, Jefferson L. Taira, Andrea M. Martins, Andrea Aparecida C. Neves, Giuliana Sigolo Surgical Resection of Lung Metastases: Results from 529 Patients |
title | Surgical Resection of Lung Metastases: Results from 529 Patients |
title_full | Surgical Resection of Lung Metastases: Results from 529 Patients |
title_fullStr | Surgical Resection of Lung Metastases: Results from 529 Patients |
title_full_unstemmed | Surgical Resection of Lung Metastases: Results from 529 Patients |
title_short | Surgical Resection of Lung Metastases: Results from 529 Patients |
title_sort | surgical resection of lung metastases: results from 529 patients |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705143/ https://www.ncbi.nlm.nih.gov/pubmed/19578657 http://dx.doi.org/10.1590/S1807-59322009000600008 |
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