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Surgical Resection of Lung Metastases: Results from 529 Patients

OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were adm...

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Autores principales: Younes, Riad N., Gross, Jefferson L., Taira, Andrea M., Martins, Andrea Aparecida C., Neves, Giuliana Sigolo
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705143/
https://www.ncbi.nlm.nih.gov/pubmed/19578657
http://dx.doi.org/10.1590/S1807-59322009000600008
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author Younes, Riad N.
Gross, Jefferson L.
Taira, Andrea M.
Martins, Andrea Aparecida C.
Neves, Giuliana Sigolo
author_facet Younes, Riad N.
Gross, Jefferson L.
Taira, Andrea M.
Martins, Andrea Aparecida C.
Neves, Giuliana Sigolo
author_sort Younes, Riad N.
collection PubMed
description OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0–192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninety-month overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection.
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spelling pubmed-27051432009-07-06 Surgical Resection of Lung Metastases: Results from 529 Patients Younes, Riad N. Gross, Jefferson L. Taira, Andrea M. Martins, Andrea Aparecida C. Neves, Giuliana Sigolo Clinics (Sao Paulo) Clinical Science OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0–192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninety-month overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2009-06 /pmc/articles/PMC2705143/ /pubmed/19578657 http://dx.doi.org/10.1590/S1807-59322009000600008 Text en Copyright © 2009 Hospital das Clínicas da FMUSP
spellingShingle Clinical Science
Younes, Riad N.
Gross, Jefferson L.
Taira, Andrea M.
Martins, Andrea Aparecida C.
Neves, Giuliana Sigolo
Surgical Resection of Lung Metastases: Results from 529 Patients
title Surgical Resection of Lung Metastases: Results from 529 Patients
title_full Surgical Resection of Lung Metastases: Results from 529 Patients
title_fullStr Surgical Resection of Lung Metastases: Results from 529 Patients
title_full_unstemmed Surgical Resection of Lung Metastases: Results from 529 Patients
title_short Surgical Resection of Lung Metastases: Results from 529 Patients
title_sort surgical resection of lung metastases: results from 529 patients
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705143/
https://www.ncbi.nlm.nih.gov/pubmed/19578657
http://dx.doi.org/10.1590/S1807-59322009000600008
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