CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus dehydration, decreased mucus transport, and mucus plugging of the airways. CFTR is normally expressed in ciliated epithelia...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Liqun, Button, Brian, Gabriel, Sherif E., Burkett, Susan, Yan, Yu, Skiadopoulos, Mario H., Dang, Yan Li, Vogel, Leatrice N., McKay, Tristan, Mengos, April, Boucher, Richard C., Collins, Peter L., Pickles, Raymond J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705187/
https://www.ncbi.nlm.nih.gov/pubmed/19621064
http://dx.doi.org/10.1371/journal.pbio.1000155

Ejemplares similares

Ejemplares similares