Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review

Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. Clinical trials have demonstrated that 50–100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates...

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Detalles Bibliográficos
Autores principales: Caputo, Fabio, Vignoli, Teo, Maremmani, Icro, Bernardi, Mauro, Zoli, Giorgio
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705225/
https://www.ncbi.nlm.nih.gov/pubmed/19578468
http://dx.doi.org/10.3390/ijerph6061917
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author Caputo, Fabio
Vignoli, Teo
Maremmani, Icro
Bernardi, Mauro
Zoli, Giorgio
author_facet Caputo, Fabio
Vignoli, Teo
Maremmani, Icro
Bernardi, Mauro
Zoli, Giorgio
author_sort Caputo, Fabio
collection PubMed
description Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. Clinical trials have demonstrated that 50–100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol. These studies have also shown that GHB craving episodes are a very limited phenomenon (about 10–15%). Thus, physicians with access should consider the clinical efficacy of GHB as a valid pharmacological tool for the treatment of alcohol addiction.
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spelling pubmed-27052252009-07-02 Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review Caputo, Fabio Vignoli, Teo Maremmani, Icro Bernardi, Mauro Zoli, Giorgio Int J Environ Res Public Health Review Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. Clinical trials have demonstrated that 50–100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol. These studies have also shown that GHB craving episodes are a very limited phenomenon (about 10–15%). Thus, physicians with access should consider the clinical efficacy of GHB as a valid pharmacological tool for the treatment of alcohol addiction. Molecular Diversity Preservation International (MDPI) 2009-06 2009-06-24 /pmc/articles/PMC2705225/ /pubmed/19578468 http://dx.doi.org/10.3390/ijerph6061917 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Caputo, Fabio
Vignoli, Teo
Maremmani, Icro
Bernardi, Mauro
Zoli, Giorgio
Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title_full Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title_fullStr Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title_full_unstemmed Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title_short Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
title_sort gamma hydroxybutyric acid (ghb) for the treatment of alcohol dependence: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705225/
https://www.ncbi.nlm.nih.gov/pubmed/19578468
http://dx.doi.org/10.3390/ijerph6061917
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