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A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk

BACKGROUND: Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH). Although meiotic recombination maps are plentiful, little is known about mitotic recombination. The APC gene (chr5q21) is mutated in most colorectal tumours and its u...

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Detalles Bibliográficos
Autores principales:	Howarth, Kimberley, Ranta, Susanna, Winter, Eitan, Teixeira, Ana, Schaschl, Helmut, Harvey, John J, Rowan, Andrew, Jones, Angela, Spain, Sarah, Clark, Susan, Guenther, Thomas, Stewart, Aengus, Silver, Andrew, Tomlinson, Ian
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705358/ https://www.ncbi.nlm.nih.gov/pubmed/19515250 http://dx.doi.org/10.1186/1471-2350-10-54

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