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A review on SNP and other types of molecular markers and their use in animal genetics

During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing g...

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Detalles Bibliográficos
Autores principales: Vignal, Alain, Milan, Denis, SanCristobal, Magali, Eggen, André
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705447/
https://www.ncbi.nlm.nih.gov/pubmed/12081799
http://dx.doi.org/10.1186/1297-9686-34-3-275
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author Vignal, Alain
Milan, Denis
SanCristobal, Magali
Eggen, André
author_facet Vignal, Alain
Milan, Denis
SanCristobal, Magali
Eggen, André
author_sort Vignal, Alain
collection PubMed
description During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types.
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spelling pubmed-27054472009-07-03 A review on SNP and other types of molecular markers and their use in animal genetics Vignal, Alain Milan, Denis SanCristobal, Magali Eggen, André Genet Sel Evol Research During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types. BioMed Central 2002-05-15 /pmc/articles/PMC2705447/ /pubmed/12081799 http://dx.doi.org/10.1186/1297-9686-34-3-275 Text en Copyright © 2002 INRA, EDP Sciences
spellingShingle Research
Vignal, Alain
Milan, Denis
SanCristobal, Magali
Eggen, André
A review on SNP and other types of molecular markers and their use in animal genetics
title A review on SNP and other types of molecular markers and their use in animal genetics
title_full A review on SNP and other types of molecular markers and their use in animal genetics
title_fullStr A review on SNP and other types of molecular markers and their use in animal genetics
title_full_unstemmed A review on SNP and other types of molecular markers and their use in animal genetics
title_short A review on SNP and other types of molecular markers and their use in animal genetics
title_sort review on snp and other types of molecular markers and their use in animal genetics
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705447/
https://www.ncbi.nlm.nih.gov/pubmed/12081799
http://dx.doi.org/10.1186/1297-9686-34-3-275
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