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A review on SNP and other types of molecular markers and their use in animal genetics
During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing g...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705447/ https://www.ncbi.nlm.nih.gov/pubmed/12081799 http://dx.doi.org/10.1186/1297-9686-34-3-275 |
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author | Vignal, Alain Milan, Denis SanCristobal, Magali Eggen, André |
author_facet | Vignal, Alain Milan, Denis SanCristobal, Magali Eggen, André |
author_sort | Vignal, Alain |
collection | PubMed |
description | During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types. |
format | Text |
id | pubmed-2705447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27054472009-07-03 A review on SNP and other types of molecular markers and their use in animal genetics Vignal, Alain Milan, Denis SanCristobal, Magali Eggen, André Genet Sel Evol Research During the last ten years, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in animal genetics studies. Amongst others, the microsatellite DNA marker has been the most widely used, due to its easy use by simple PCR, followed by a denaturing gel electrophoresis for allele size determination, and to the high degree of information provided by its large number of alleles per locus. Despite this, a new marker type, named SNP, for Single Nucleotide Polymorphism, is now on the scene and has gained high popularity, even though it is only a bi-allelic type of marker. In this review, we will discuss the reasons for this apparent step backwards, and the pertinence of the use of SNPs in animal genetics, in comparison with other marker types. BioMed Central 2002-05-15 /pmc/articles/PMC2705447/ /pubmed/12081799 http://dx.doi.org/10.1186/1297-9686-34-3-275 Text en Copyright © 2002 INRA, EDP Sciences |
spellingShingle | Research Vignal, Alain Milan, Denis SanCristobal, Magali Eggen, André A review on SNP and other types of molecular markers and their use in animal genetics |
title | A review on SNP and other types of molecular markers and their use in animal genetics |
title_full | A review on SNP and other types of molecular markers and their use in animal genetics |
title_fullStr | A review on SNP and other types of molecular markers and their use in animal genetics |
title_full_unstemmed | A review on SNP and other types of molecular markers and their use in animal genetics |
title_short | A review on SNP and other types of molecular markers and their use in animal genetics |
title_sort | review on snp and other types of molecular markers and their use in animal genetics |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705447/ https://www.ncbi.nlm.nih.gov/pubmed/12081799 http://dx.doi.org/10.1186/1297-9686-34-3-275 |
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