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Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep

Inheritance of the ovulation rate (OR) in the Lacaune meat breed was studied through records from a small nucleus of 36 hyper-prolific ewes screened on farms on the basis of their natural litter size, and from progeny data of three selected Lacaune sires. These sires were chosen at the AI centre acc...

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Autores principales: Bodin, Loys, SanCristobal, Magali, Lecerf, Frédéric, Mulsant, Philippe, Bibé, Bernard, Lajous, Daniel, Belloc, Jean-Pierre, Eychenne, Francis, Amigues, Yves, Elsen, Jean-Michel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705455/
https://www.ncbi.nlm.nih.gov/pubmed/12270104
http://dx.doi.org/10.1186/1297-9686-34-4-447
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author Bodin, Loys
SanCristobal, Magali
Lecerf, Frédéric
Mulsant, Philippe
Bibé, Bernard
Lajous, Daniel
Belloc, Jean-Pierre
Eychenne, Francis
Amigues, Yves
Elsen, Jean-Michel
author_facet Bodin, Loys
SanCristobal, Magali
Lecerf, Frédéric
Mulsant, Philippe
Bibé, Bernard
Lajous, Daniel
Belloc, Jean-Pierre
Eychenne, Francis
Amigues, Yves
Elsen, Jean-Michel
author_sort Bodin, Loys
collection PubMed
description Inheritance of the ovulation rate (OR) in the Lacaune meat breed was studied through records from a small nucleus of 36 hyper-prolific ewes screened on farms on the basis of their natural litter size, and from progeny data of three selected Lacaune sires. These sires were chosen at the AI centre according to their breeding values estimated for the mean and the variability of their daughters' litter size. Non-carrier Lacaune dairy ewes were inseminated to produce 121 F1 daughters and 27 F1 sons. Twelve sons (four from each sire) were used in turn to inseminate non-carrier Lacaune dairy ewes providing 260 BC progeny ewes. F1 and BC progeny were brought from private farms and gathered after weaning on an experimental farm where ovulation rates were recorded in the first and second breeding seasons. With an average of 6.5 records each, the mean OR of hyper-prolific ewes was very high (5.34), and 38.4% of records showed a rate of 6 or more. F1 data showed high repeatability of OR (r = 0.54) within ewe, with significant variability among ewes. High OR (≥ 4) were observed in each family. A segregation analysis provided a significant likelihood ratio and classified the three founders as heterozygous. BC ewes also displayed high repeatability of OR (r = 0.47) and the mean OR varied considerably between families (from 1.24 to 1.78). Seven of the 12 BC families presented high-ovulating ewes (at least one record ≥ 4) and segregation analysis yielded a highly significant likelihood ratio as compared to an empirical test distribution. The high variability of the mean ovulation rate shown by a small group of daughters of BC ewes inseminated by putative carrier F1 rams, and the very high ovulation rate observed for some of these ewe lambs, confirmed the segregation of a major gene with two co-dominant alleles borne by an autosome. The difference between homozygous non-carriers and heterozygous ewes was about one ovulation on the observed scale and 2.2 standard deviations on the underlying scale.
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spelling pubmed-27054552009-07-03 Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep Bodin, Loys SanCristobal, Magali Lecerf, Frédéric Mulsant, Philippe Bibé, Bernard Lajous, Daniel Belloc, Jean-Pierre Eychenne, Francis Amigues, Yves Elsen, Jean-Michel Genet Sel Evol Research Inheritance of the ovulation rate (OR) in the Lacaune meat breed was studied through records from a small nucleus of 36 hyper-prolific ewes screened on farms on the basis of their natural litter size, and from progeny data of three selected Lacaune sires. These sires were chosen at the AI centre according to their breeding values estimated for the mean and the variability of their daughters' litter size. Non-carrier Lacaune dairy ewes were inseminated to produce 121 F1 daughters and 27 F1 sons. Twelve sons (four from each sire) were used in turn to inseminate non-carrier Lacaune dairy ewes providing 260 BC progeny ewes. F1 and BC progeny were brought from private farms and gathered after weaning on an experimental farm where ovulation rates were recorded in the first and second breeding seasons. With an average of 6.5 records each, the mean OR of hyper-prolific ewes was very high (5.34), and 38.4% of records showed a rate of 6 or more. F1 data showed high repeatability of OR (r = 0.54) within ewe, with significant variability among ewes. High OR (≥ 4) were observed in each family. A segregation analysis provided a significant likelihood ratio and classified the three founders as heterozygous. BC ewes also displayed high repeatability of OR (r = 0.47) and the mean OR varied considerably between families (from 1.24 to 1.78). Seven of the 12 BC families presented high-ovulating ewes (at least one record ≥ 4) and segregation analysis yielded a highly significant likelihood ratio as compared to an empirical test distribution. The high variability of the mean ovulation rate shown by a small group of daughters of BC ewes inseminated by putative carrier F1 rams, and the very high ovulation rate observed for some of these ewe lambs, confirmed the segregation of a major gene with two co-dominant alleles borne by an autosome. The difference between homozygous non-carriers and heterozygous ewes was about one ovulation on the observed scale and 2.2 standard deviations on the underlying scale. BioMed Central 2002-07-15 /pmc/articles/PMC2705455/ /pubmed/12270104 http://dx.doi.org/10.1186/1297-9686-34-4-447 Text en Copyright © 2002 INRA, EDP Sciences
spellingShingle Research
Bodin, Loys
SanCristobal, Magali
Lecerf, Frédéric
Mulsant, Philippe
Bibé, Bernard
Lajous, Daniel
Belloc, Jean-Pierre
Eychenne, Francis
Amigues, Yves
Elsen, Jean-Michel
Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title_full Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title_fullStr Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title_full_unstemmed Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title_short Segregation of a major gene influencing ovulation in progeny of Lacaune meat sheep
title_sort segregation of a major gene influencing ovulation in progeny of lacaune meat sheep
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705455/
https://www.ncbi.nlm.nih.gov/pubmed/12270104
http://dx.doi.org/10.1186/1297-9686-34-4-447
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