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Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis
Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decreas...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705774/ https://www.ncbi.nlm.nih.gov/pubmed/19587826 http://dx.doi.org/10.1155/2009/623871 |
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author | Klar, A. Haver, E. Lichtstein, D. Hurvitz, H. Foah-Shauli, T. |
author_facet | Klar, A. Haver, E. Lichtstein, D. Hurvitz, H. Foah-Shauli, T. |
author_sort | Klar, A. |
collection | PubMed |
description | Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 ± 11 pg/ml versus 13.4 ± 12 pg/ml respectively, and 3 ± 2 versus 3.8 ± 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found r = 0.29. The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group. |
format | Text |
id | pubmed-2705774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27057742009-07-08 Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis Klar, A. Haver, E. Lichtstein, D. Hurvitz, H. Foah-Shauli, T. Gastroenterol Res Pract Research Article Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 ± 11 pg/ml versus 13.4 ± 12 pg/ml respectively, and 3 ± 2 versus 3.8 ± 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found r = 0.29. The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group. Hindawi Publishing Corporation 2009 2009-07-01 /pmc/articles/PMC2705774/ /pubmed/19587826 http://dx.doi.org/10.1155/2009/623871 Text en Copyright © 2009 A. Klar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Klar, A. Haver, E. Lichtstein, D. Hurvitz, H. Foah-Shauli, T. Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title_full | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title_fullStr | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title_full_unstemmed | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title_short | Atrial Natriuretic Peptide in Young and Elderly Children with Mild Gastroenteritis |
title_sort | atrial natriuretic peptide in young and elderly children with mild gastroenteritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705774/ https://www.ncbi.nlm.nih.gov/pubmed/19587826 http://dx.doi.org/10.1155/2009/623871 |
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