Cargando…

Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice

Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and humoral immune response. We have previously determined altered tyrosine phosphorylation patterns within hCR2 transgenic mice, suggesting that irreversible changes in B cell signaling pathways had...

Descripción completa

Detalles Bibliográficos
Autores principales:	Twohig, Jason P., Pappworth, Isabel Y., Sivasankar, Baalasubramanian, Kulik, Liudmila, Bull, Melanie, Holers, V. Michael, Wang, Eddie C.Y., Marchbank, Kevin J.
Formato:	Texto
Lenguaje:	English
Publicado:	Pergamon Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706330/ https://www.ncbi.nlm.nih.gov/pubmed/19359041 http://dx.doi.org/10.1016/j.molimm.2009.03.007

Ejemplares similares

Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21)
por: Pappworth, Isabel Y., et al.
Publicado: (2009)

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice
por: He, Yong-Gang, et al.
Publicado: (2018)

Deficiency of complement receptors CR2/CR1 in Cr2(-/-) mice reduces the extent of secondary brain damage after closed head injury
por: Neher, Miriam D, et al.
Publicado: (2014)

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice
por: Smith-Jackson, Kate, et al.
Publicado: (2019)

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility
por: Donev, Rossen M., et al.
Publicado: (2008)

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy
por: Nichols, Eva-Maria, et al.
Publicado: (2015)

Retraction notice to “The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility” [Mol. Immunol. 45 (2008) 534–542]
por: Donev, Rossen M., et al.
Publicado: (2014)

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)
por: Gordon, Lucy, et al.
Publicado: (2022)

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement
por: Narang, Aarti, et al.
Publicado: (2017)

Evaluating the B-cell C3d:CR2 innate-adaptive immune interaction as a therapeutic target in lupus
por: Holers, VM, et al.
Publicado: (2012)

C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice
por: Banda, Nirmal K., et al.
Publicado: (2020)

Complement-Activating IgM Enhances the Humoral but Not the T Cell Immune Response in Mice
por: Ding, Zhoujie, et al.
Publicado: (2013)

Vocal Ontogeny in Neotropical Singing Mice (Scotinomys)
por: Campbell, Polly, et al.
Publicado: (2014)

IgM exacerbates glomerular disease progression in complement induced glomerulopathy
por: Panzer, Sarah E., et al.
Publicado: (2015)

Ontogeny of ependymoglial cells lining the third ventricle in mice
por: Lopez-Rodriguez, David, et al.
Publicado: (2023)

Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59
por: Hughes, Timothy R., et al.
Publicado: (2009)

ONTOGENY OF BURSAL FUNCTION IN CHICKEN : III. IMMUNOCOMPETENT CELL FOR HUMORAL IMMUNITY
por: Toivanen, Paavo, et al.
Publicado: (1972)

ACUTE DESTRUCTION BY HUMORAL ANTIBODY OF RAT SKIN GRAFTED TO MICE : THE ROLE OF COMPLEMENT AND POLYMORPHONUCLEAR LEUKOCYTES
por: Winn, Henry J., et al.
Publicado: (1973)

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice
por: Mihai, Sidonia, et al.
Publicado: (2018)

P791: COMMON VARIANTS IN COMPLEMENT PROTEINS, C3 AND CR1, ENHANCE COMPLEMENT ATTACK ON PNH ERYTHROCYTES AND INCREASE RISK FOR EXTRAVASCULAR HAEMOLYSIS
por: Baral, A. J., et al.
Publicado: (2022)

Studies on the humoral regulation of granulopoiesis in leukaemic RFM mice.
por: Gordon, M. Y., et al.
Publicado: (1975)

Complement Mediated Signaling on Pulmonary CD103(+) Dendritic Cells Is Critical for Their Migratory Function in Response to Influenza Infection
por: Kandasamy, Matheswaran, et al.
Publicado: (2013)

Microglia, seen from the CX(3)CR1 angle
por: Wolf, Yochai, et al.
Publicado: (2013)

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice
por: Kerr, Heather, et al.
Publicado: (2021)

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice
por: Kane, Sarah J., et al.
Publicado: (2017)

Ontogeny of Hepatic Energy Metabolism Genes in Mice as Revealed by RNA-Sequencing
por: Renaud, Helen J., et al.
Publicado: (2014)

Ontogeny, distribution and function of CD38-expressing B lymphocytes in mice
por: Donís-Hernández, Felipe Raúl, et al.
Publicado: (2001)

Transgenic Mice Overexpressing the Complement Inhibitor Crry as a Soluble Protein Are Protected from Antibody-induced Glomerular Injury
por: Quigg, Richard J., et al.
Publicado: (1998)

Complement in the Initiation and Evolution of Rheumatoid Arthritis
por: Holers, V. Michael, et al.
Publicado: (2018)

Humoral immunostimulation. IV. Role of complement
Publicado: (1975)

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice
por: Kamala, Ola, et al.
Publicado: (2021)

Tissue-specific phosphorylation of complement receptors CR1 and CR2
Publicado: (1986)

Antigen-Independent Selection of T15 Idiotype During B-Cell Ontogeny In Mice
por: Vakil, Meenal, et al.
Publicado: (1991)

Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice
Publicado: (1977)

MATURATION OF THE HUMORAL IMMUNE RESPONSE IN MICE
por: Spear, Patricia G., et al.
Publicado: (1974)

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation
por: Tediose, Teeo, et al.
Publicado: (2010)

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation
por: Tediose, Teeo, et al.
Publicado: (2014)

Contribution of natural food environments to nutritional intake and biomarker status: insights from the women of indigenous santhal communities of Jharkhand, India
por: Singh, Archna, et al.
Publicado: (2023)

Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors Cr1 and Cr2
por: Chen, Zhibin, et al.
Publicado: (2000)

Extrathymic T Cell Lymphopoiesis: Ontogeny and Contribution to Gut Intraepithelial Lymphocytes in Athymic and Euthymic Mice
por: Guy-Grand, Delphine, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_o56rft4r7lq24bsk6bh2fe5ltv