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The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2

αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TR...

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Detalles Bibliográficos
Autores principales: Reinink, Peter, Van Rhijn, Ildiko
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706379/
https://www.ncbi.nlm.nih.gov/pubmed/19568741
http://dx.doi.org/10.1007/s00251-009-0384-9
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author Reinink, Peter
Van Rhijn, Ildiko
author_facet Reinink, Peter
Van Rhijn, Ildiko
author_sort Reinink, Peter
collection PubMed
description αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0384-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-27063792009-07-08 The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 Reinink, Peter Van Rhijn, Ildiko Immunogenetics Original Paper αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0384-9) contains supplementary material, which is available to authorized users. Springer-Verlag 2009-07-02 2009-07 /pmc/articles/PMC2706379/ /pubmed/19568741 http://dx.doi.org/10.1007/s00251-009-0384-9 Text en © The Author(s) 2009
spellingShingle Original Paper
Reinink, Peter
Van Rhijn, Ildiko
The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title_full The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title_fullStr The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title_full_unstemmed The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title_short The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
title_sort bovine t cell receptor alpha/delta locus contains over 400 v genes and encodes v genes without cdr2
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706379/
https://www.ncbi.nlm.nih.gov/pubmed/19568741
http://dx.doi.org/10.1007/s00251-009-0384-9
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