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The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TR...
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706379/ https://www.ncbi.nlm.nih.gov/pubmed/19568741 http://dx.doi.org/10.1007/s00251-009-0384-9 |
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author | Reinink, Peter Van Rhijn, Ildiko |
author_facet | Reinink, Peter Van Rhijn, Ildiko |
author_sort | Reinink, Peter |
collection | PubMed |
description | αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0384-9) contains supplementary material, which is available to authorized users. |
format | Text |
id | pubmed-2706379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-27063792009-07-08 The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 Reinink, Peter Van Rhijn, Ildiko Immunogenetics Original Paper αβ T cells and γδ T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse γδ T cells, like ruminants and pigs, it is often assumed that αβ T cells are less diverse than γδ T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0384-9) contains supplementary material, which is available to authorized users. Springer-Verlag 2009-07-02 2009-07 /pmc/articles/PMC2706379/ /pubmed/19568741 http://dx.doi.org/10.1007/s00251-009-0384-9 Text en © The Author(s) 2009 |
spellingShingle | Original Paper Reinink, Peter Van Rhijn, Ildiko The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title | The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title_full | The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title_fullStr | The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title_full_unstemmed | The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title_short | The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2 |
title_sort | bovine t cell receptor alpha/delta locus contains over 400 v genes and encodes v genes without cdr2 |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706379/ https://www.ncbi.nlm.nih.gov/pubmed/19568741 http://dx.doi.org/10.1007/s00251-009-0384-9 |
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