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KIR gene content diversity in four Iranian populations

Killer cell immunoglobulin-like receptors (KIR) regulate natural killer cell response against infection and malignancy. KIR genes are variable in the number and type, thereby discriminating individuals and populations. Herein, we analyzed the KIR gene content diversity in four native populations of...

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Detalles Bibliográficos
Autores principales: Ashouri, Elham, Farjadian, Shirin, Reed, Elaine F., Ghaderi, Abbas, Rajalingam, Raja
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706385/
https://www.ncbi.nlm.nih.gov/pubmed/19521696
http://dx.doi.org/10.1007/s00251-009-0378-7
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author Ashouri, Elham
Farjadian, Shirin
Reed, Elaine F.
Ghaderi, Abbas
Rajalingam, Raja
author_facet Ashouri, Elham
Farjadian, Shirin
Reed, Elaine F.
Ghaderi, Abbas
Rajalingam, Raja
author_sort Ashouri, Elham
collection PubMed
description Killer cell immunoglobulin-like receptors (KIR) regulate natural killer cell response against infection and malignancy. KIR genes are variable in the number and type, thereby discriminating individuals and populations. Herein, we analyzed the KIR gene content diversity in four native populations of Iran. The KIR genomic diversity was comparable between Bakhtiari and Persian and displayed a balance of A and B KIR haplotypes, a trend reported in Caucasian and African populations. The KIR gene content profiles of Arab and Azeri were comparable and displayed a preponderance of B haplotypes, a scenario reported in the natives of America, India, and Australia. A majority of the B haplotype carriers of Azeri and Arab had a centromeric gene-cluster (KIR2DS2-2DL2-2DS3-2DL5). Remarkably, this cluster was totally absent from the American natives but occurred at highest frequencies in the natives of India and Australia in combination with another gene cluster at the telomeric region (KIR3DS1-2DL5-2DS5-2DS1). Therefore, despite having similar frequencies of B haplotypes, the occurrence of B haplotype-specific KIR genes, such as 2DL2, 2DL5, 3DS1, 2DS1, 2DS2, 2DS3, and 2DS5 in Azeri and Arab were substantially different from the natives of America, India, and Australia. In conclusion, each Iranian population exhibits distinct KIR gene content diversity, and the Indo-European KIR genetic signatures of the Iranians concur with geographic proximity, linguistic affinity, and human migrations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0378-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-27063852009-07-08 KIR gene content diversity in four Iranian populations Ashouri, Elham Farjadian, Shirin Reed, Elaine F. Ghaderi, Abbas Rajalingam, Raja Immunogenetics Original Paper Killer cell immunoglobulin-like receptors (KIR) regulate natural killer cell response against infection and malignancy. KIR genes are variable in the number and type, thereby discriminating individuals and populations. Herein, we analyzed the KIR gene content diversity in four native populations of Iran. The KIR genomic diversity was comparable between Bakhtiari and Persian and displayed a balance of A and B KIR haplotypes, a trend reported in Caucasian and African populations. The KIR gene content profiles of Arab and Azeri were comparable and displayed a preponderance of B haplotypes, a scenario reported in the natives of America, India, and Australia. A majority of the B haplotype carriers of Azeri and Arab had a centromeric gene-cluster (KIR2DS2-2DL2-2DS3-2DL5). Remarkably, this cluster was totally absent from the American natives but occurred at highest frequencies in the natives of India and Australia in combination with another gene cluster at the telomeric region (KIR3DS1-2DL5-2DS5-2DS1). Therefore, despite having similar frequencies of B haplotypes, the occurrence of B haplotype-specific KIR genes, such as 2DL2, 2DL5, 3DS1, 2DS1, 2DS2, 2DS3, and 2DS5 in Azeri and Arab were substantially different from the natives of America, India, and Australia. In conclusion, each Iranian population exhibits distinct KIR gene content diversity, and the Indo-European KIR genetic signatures of the Iranians concur with geographic proximity, linguistic affinity, and human migrations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-009-0378-7) contains supplementary material, which is available to authorized users. Springer-Verlag 2009-06-12 2009-07 /pmc/articles/PMC2706385/ /pubmed/19521696 http://dx.doi.org/10.1007/s00251-009-0378-7 Text en © The Author(s) 2009
spellingShingle Original Paper
Ashouri, Elham
Farjadian, Shirin
Reed, Elaine F.
Ghaderi, Abbas
Rajalingam, Raja
KIR gene content diversity in four Iranian populations
title KIR gene content diversity in four Iranian populations
title_full KIR gene content diversity in four Iranian populations
title_fullStr KIR gene content diversity in four Iranian populations
title_full_unstemmed KIR gene content diversity in four Iranian populations
title_short KIR gene content diversity in four Iranian populations
title_sort kir gene content diversity in four iranian populations
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706385/
https://www.ncbi.nlm.nih.gov/pubmed/19521696
http://dx.doi.org/10.1007/s00251-009-0378-7
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