Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function

Germline and somatic PTEN mutations are found in Cowden syndrome (CS) and multiple sporadic malignancies, respectively. PTEN function appears to be modulated by subcellular compartmentalization, and mislocalization may affect function. We have shown that cellular ATP levels affect nuclear PTEN level...

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Detalles Bibliográficos
Autores principales: Lobo, Glenn P., Waite, Kristin A., Planchon, Sarah M., Romigh, Todd, Nassif, Najah T., Eng, Charis
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706686/
https://www.ncbi.nlm.nih.gov/pubmed/19457929
http://dx.doi.org/10.1093/hmg/ddp220

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