Cargando…
The porcine Major Histocompatibility Complex and related paralogous regions: a review
The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the clas...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2000
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706865/ https://www.ncbi.nlm.nih.gov/pubmed/14736397 http://dx.doi.org/10.1186/1297-9686-32-2-109 |
_version_ | 1782169104930570240 |
---|---|
author | Chardon, Patrick Renard, Christine Gaillard, Claire Rogel Vaiman, Marcel |
author_facet | Chardon, Patrick Renard, Christine Gaillard, Claire Rogel Vaiman, Marcel |
author_sort | Chardon, Patrick |
collection | PubMed |
description | The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits. |
format | Text |
id | pubmed-2706865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27068652009-07-08 The porcine Major Histocompatibility Complex and related paralogous regions: a review Chardon, Patrick Renard, Christine Gaillard, Claire Rogel Vaiman, Marcel Genet Sel Evol Research The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits. BioMed Central 2000-03-15 /pmc/articles/PMC2706865/ /pubmed/14736397 http://dx.doi.org/10.1186/1297-9686-32-2-109 Text en Copyright © 2000 INRA, EDP Sciences |
spellingShingle | Research Chardon, Patrick Renard, Christine Gaillard, Claire Rogel Vaiman, Marcel The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title | The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title_full | The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title_fullStr | The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title_full_unstemmed | The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title_short | The porcine Major Histocompatibility Complex and related paralogous regions: a review |
title_sort | porcine major histocompatibility complex and related paralogous regions: a review |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706865/ https://www.ncbi.nlm.nih.gov/pubmed/14736397 http://dx.doi.org/10.1186/1297-9686-32-2-109 |
work_keys_str_mv | AT chardonpatrick theporcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT renardchristine theporcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT gaillardclairerogel theporcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT vaimanmarcel theporcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT chardonpatrick porcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT renardchristine porcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT gaillardclairerogel porcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview AT vaimanmarcel porcinemajorhistocompatibilitycomplexandrelatedparalogousregionsareview |