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LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors

LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration cofactor role for these retroviruses is unclear. While a single integrase binding domain (IBD) binds integrase, a complex N-terminal domain ensemble (NDE) interacts with unknown chro...

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Detalles Bibliográficos
Autores principales:	Meehan, Anne M., Saenz, Dyana T., Morrison, James H., Garcia-Rivera, Jose A., Peretz, Mary, Llano, Manuel, Poeschla, Eric M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706977/ https://www.ncbi.nlm.nih.gov/pubmed/19609362 http://dx.doi.org/10.1371/journal.ppat.1000522

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