Cargando…

Lys169 of Human Glucokinase Is a Determinant for Glucose Phosphorylation: Implication for the Atomic Mechanism of Glucokinase Catalysis

Glucokinase (GK), a glucose sensor, maintains plasma glucose homeostasis via phosphorylation of glucose and is a potential therapeutic target for treating maturity-onset diabetes of the young (MODY) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). To characterize the catalytic mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jian, Li, Chenjing, Shi, Ting, Chen, Kaixian, Shen, Xu, Jiang, Hualiang
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706991/ https://www.ncbi.nlm.nih.gov/pubmed/19617908 http://dx.doi.org/10.1371/journal.pone.0006304

Ejemplares similares

Heterozygous lys169Glu mutation of glucokinase gene in a Chinese family having glucokinase-maturity-onset diabetes of the young (GCK-MODY)
por: Zhou, W, et al.
Publicado: (2019)

Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity
por: Park, Joo-Man, et al.
Publicado: (2015)

Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein
por: Jin, Ling, et al.
Publicado: (2015)

Arcuate nucleus glucokinase and dietary glucose intake
por: Ma, Yue, et al.
Publicado: (2015)

Ebb and Tide of Glucokinase
por: Matschinsky, Franz M.
Publicado: (2001)

Comparative Structural and Functional Analysis of Staphylococcus aureus Glucokinase with other Bacterial Glucokinases
por: Kumar, P. S., et al.
Publicado: (2014)

Evolution of Hepatic Glucose Metabolism: Liver-Specific Glucokinase Deficiency Explained by Parallel Loss of the Gene for Glucokinase Regulatory Protein (GCKR)
por: Wang, Zhao Yang, et al.
Publicado: (2013)

Molecular Physiology of Mammalian Glucokinase
por: Iynedjian, P. B.
Publicado: (2008)

Insights into the role of neuronal glucokinase
por: De Backer, Ivan, et al.
Publicado: (2016)

Conformational Transition Pathway in the Activation Process of Allosteric Glucokinase
por: Huang, Min, et al.
Publicado: (2013)

α-cell glucokinase suppresses glucose-regulated glucagon secretion
por: Basco, Davide, et al.
Publicado: (2018)

UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4
por: Yellapu, Nanda Kumar, et al.
Publicado: (2018)

Cloning and characterization of feline islet glucokinase
por: Lindbloom-Hawley, Sara, et al.
Publicado: (2014)

Thermal Stability of Glucokinases in Thermoanaerobacter tengcongensis
por: Qian, Zhong, et al.
Publicado: (2013)

Citrullination of glucokinase is linked to autoimmune diabetes
por: Yang, Mei-Ling, et al.
Publicado: (2022)

Structural Variations of Human Glucokinase Glu256Lys in MODY2 Condition Using Molecular Dynamics Study
por: Yellapu, Nanda Kumar, et al.
Publicado: (2013)

A Panel of Diverse Assays to Interrogate the Interaction between Glucokinase and Glucokinase Regulatory Protein, Two Vital Proteins in Human Disease
por: Rees, Matthew G., et al.
Publicado: (2014)

Brain glucose sensing, glucokinase and neural control of metabolism and islet function
por: Ogunnowo-Bada, E O, et al.
Publicado: (2014)

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis
por: Ma, Yue, et al.
Publicado: (2018)

A glucokinase-linked sensor in the taste system contributes to glucose appetite
por: Chometton, Sandrine, et al.
Publicado: (2022)

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver
por: Roncero, Isabel, et al.
Publicado: (2013)

Present status of clinical deployment of glucokinase activators
por: Nakamura, Akinobu, et al.
Publicado: (2015)

Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents
por: Tam, Claudia H.T., et al.
Publicado: (2009)

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes
por: Chow, Elaine, et al.
Publicado: (2023)

Phosphorylation of Staphylococcus aureus Protein-Tyrosine Kinase Affects the Function of Glucokinase and Biofilm Formation
por: Vasu, Dudipeta, et al.
Publicado: (2017)

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
por: Watanabe, Hitoshi, et al.
Publicado: (2018)

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells
por: Moede, Tilo, et al.
Publicado: (2020)

Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status
por: Marqués, Patricia, et al.
Publicado: (2019)

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption
por: Kessler, Sébastien, et al.
Publicado: (2021)

Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice
por: Adingupu, Damilola D., et al.
Publicado: (2016)

Decreased expression of hepatic glucokinase in type 2 diabetes
por: Haeusler, Rebecca A., et al.
Publicado: (2014)

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
por: Kishore, Madhav, et al.
Publicado: (2017)

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
por: Kishore, Madhav, et al.
Publicado: (2018)

ATP- and Polyphosphate-Dependent Glucokinases from Aerobic Methanotrophs
por: Reshetnikov, Alexander S., et al.
Publicado: (2019)

A comprehensive map of human glucokinase variant activity
por: Gersing, Sarah, et al.
Publicado: (2023)

Ischemic preconditioning maintains immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia
por: Cho, JH, et al.
Publicado: (2015)

Ischemic preconditioning maintains the immunoreactivities of glucokinase and glucokinase regulatory protein in neurons of the gerbil hippocampal CA1 region following transient cerebral ischemia
por: CHO, YOUNG SHIN, et al.
Publicado: (2015)

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
por: Al-aryahi, Sefaa, et al.
Publicado: (2014)

ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing
por: Imle, Roland, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f7tnq2t24t42cqdr3qjc8d9ijs