Cargando…

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of α-ketoesters is reported.

Detalles Bibliográficos
Autores principales:	Palmieri, Alessandro, Ley, Steven V, Polyzos, Anastasios, Ladlow, Mark, Baxendale, Ian R
Formato:	Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2009
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707014/ https://www.ncbi.nlm.nih.gov/pubmed/19590738 http://dx.doi.org/10.3762/bjoc.5.23

Ejemplares similares

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
por: Roper, Kimberley A, et al.
Publicado: (2011)

Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters
por: Hintermann, Lukas, et al.
Publicado: (2011)

NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
por: He, Lin, et al.
Publicado: (2013)

Towards an asymmetric organocatalytic α-cyanation of β-ketoesters
por: Chowdhury, Raghunath, et al.
Publicado: (2015)

Towards an Asymmetric Organocatalytic α-Azidation of β-Ketoesters
por: Tiffner, Maximilian, et al.
Publicado: (2018)

Enantiospecific deoxyfluorination of cyclic α-OH-β-ketoesters†
por: Mairhofer, Christopher, et al.
Publicado: (2021)

Trityl Cation-Catalyzed Hosomi-Sakurai Reaction of Allylsilane with β,γ-Unsaturated α-Ketoester to Form γ,γ-Disubstituted α-Ketoesters
por: Gan, Zubao, et al.
Publicado: (2022)

Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides
por: Roslan, Irwan Iskandar, et al.
Publicado: (2017)

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry
por: Baumann, Marcus, et al.
Publicado: (2015)

Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose
por: Stanetty, Christian, et al.
Publicado: (2015)

Vicinal ketoesters – key intermediates in the total synthesis of natural products
por: Beller, Marc Paul, et al.
Publicado: (2022)

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
por: Baumann, Marcus, et al.
Publicado: (2017)

Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters
por: Yi, Wen-Bin, et al.
Publicado: (2012)

Development of an Enantioselective Allylic Alkylation of Acyclic α‐Fluoro‐β‐ketoesters for Asymmetric Synthesis of 3‐Fluoropiperidines
por: Han, Jiaxin, et al.
Publicado: (2022)

DBU-Mediated Addition of α-Nitroketones to α-Cyano-enones and α,β-Unsaturated α-Ketoesters: Synthesis of Dihydrofurans and Conjugated Dienes
por: Sahoo, Subas Chandra, et al.
Publicado: (2019)

The rapid generation of isothiocyanates in flow
por: Baumann, Marcus, et al.
Publicado: (2013)

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry
por: Lücke, Daniel, et al.
Publicado: (2016)

Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination
por: Yao, Peiyuan, et al.
Publicado: (2021)

Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters
por: Woźniak, Łukasz, et al.
Publicado: (2015)

Regioselective α-addition of vinylogous α-ketoester enolate in organocatalytic asymmetric Michael reactions: enantioselective synthesis of Rauhut–Currier type products
por: Weng, Zhibing, et al.
Publicado: (2022)

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides
por: Hossain, Md Imran, et al.
Publicado: (2022)

Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines
por: Kan, Sha-Sha, et al.
Publicado: (2011)

Synergistic Ammonium (Hypo)Iodite/Imine Catalysis for the Asymmetric α-Hydroxylation of β-Ketoesters
por: Mairhofer, Christopher, et al.
Publicado: (2020)

Further developments of β,γ-unsaturated α-ketoesters as versatile synthons in asymmetric catalysis
por: Deng, Ruixian, et al.
Publicado: (2022)

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
por: Baumann, Marcus, et al.
Publicado: (2014)

Synthesis of 2,3-Dialkylated Tartaric Acid Esters via Visible Light Photoredox-Catalyzed Reductive Dimerization of α-Ketoesters
por: Zhu, Jing, et al.
Publicado: (2017)

Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters
por: Yamamoto, Yasunori, et al.
Publicado: (2011)

Flow carbonylation of sterically hindered ortho-substituted iodoarenes
por: Mallia, Carl J, et al.
Publicado: (2016)

Scaled up and telescoped synthesis of propofol under continuous-flow conditions
por: Martins, Guilherme M., et al.
Publicado: (2022)

Controlled synthesis of poly(3-hexylthiophene) in continuous flow
por: Seyler, Helga, et al.
Publicado: (2013)

Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer’s
por: Sadiq, Abdul, et al.
Publicado: (2015)

Efficient Synthesis of 3H-Indoles Enabled by the Lead-Mediated α-Arylation of β-Ketoesters or γ-Lactams Using Aryl Azides
por: Zhou, Fei, et al.
Publicado: (2014)

Nanofiltration‐Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous‐Flow Synthesis
por: Fodi, Tamas, et al.
Publicado: (2017)

High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine
por: Yu, Eric, et al.
Publicado: (2018)

Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction
por: Griwatz, Jan H, et al.
Publicado: (2022)

Polycyclizations of Ketoesters: Synthesis of Complex Tricycles with up to Five Stereogenic Centers from Available Starting Materials
por: Kamlar, Martin, et al.
Publicado: (2020)

Continuous flow photocyclization of stilbenes – scalable synthesis of functionalized phenanthrenes and helicenes
por: Lefebvre, Quentin, et al.
Publicado: (2013)

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin
por: Orosz, János Máté, et al.
Publicado: (2023)

Nitro-enabled catalytic enantioselective formal umpolung alkenylation of β-ketoesters
por: Choudhury, Abhijnan Ray, et al.
Publicado: (2017)

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin
por: Pastre, Julio C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ccg03rp4gsbr15mpvvg33f9sf1