Cargando…

From discovery to production: Scale-out of continuous flow meso reactors

A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Styring, Peter, Parracho, Ana I R
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707018/
https://www.ncbi.nlm.nih.gov/pubmed/19590741
http://dx.doi.org/10.3762/bjoc.5.29
_version_ 1782169124723490816
author Styring, Peter
Parracho, Ana I R
author_facet Styring, Peter
Parracho, Ana I R
author_sort Styring, Peter
collection PubMed
description A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.
format Text
id pubmed-2707018
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-27070182009-07-09 From discovery to production: Scale-out of continuous flow meso reactors Styring, Peter Parracho, Ana I R Beilstein J Org Chem Full Research Paper A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch. Beilstein-Institut 2009-06-09 /pmc/articles/PMC2707018/ /pubmed/19590741 http://dx.doi.org/10.3762/bjoc.5.29 Text en Copyright © 2009, Styring and Parracho https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Styring, Peter
Parracho, Ana I R
From discovery to production: Scale-out of continuous flow meso reactors
title From discovery to production: Scale-out of continuous flow meso reactors
title_full From discovery to production: Scale-out of continuous flow meso reactors
title_fullStr From discovery to production: Scale-out of continuous flow meso reactors
title_full_unstemmed From discovery to production: Scale-out of continuous flow meso reactors
title_short From discovery to production: Scale-out of continuous flow meso reactors
title_sort from discovery to production: scale-out of continuous flow meso reactors
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707018/
https://www.ncbi.nlm.nih.gov/pubmed/19590741
http://dx.doi.org/10.3762/bjoc.5.29
work_keys_str_mv AT styringpeter fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors
AT parrachoanair fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors