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From discovery to production: Scale-out of continuous flow meso reactors
A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions ca...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Beilstein-Institut
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707018/ https://www.ncbi.nlm.nih.gov/pubmed/19590741 http://dx.doi.org/10.3762/bjoc.5.29 |
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author | Styring, Peter Parracho, Ana I R |
author_facet | Styring, Peter Parracho, Ana I R |
author_sort | Styring, Peter |
collection | PubMed |
description | A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch. |
format | Text |
id | pubmed-2707018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-27070182009-07-09 From discovery to production: Scale-out of continuous flow meso reactors Styring, Peter Parracho, Ana I R Beilstein J Org Chem Full Research Paper A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch. Beilstein-Institut 2009-06-09 /pmc/articles/PMC2707018/ /pubmed/19590741 http://dx.doi.org/10.3762/bjoc.5.29 Text en Copyright © 2009, Styring and Parracho https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Styring, Peter Parracho, Ana I R From discovery to production: Scale-out of continuous flow meso reactors |
title | From discovery to production: Scale-out of continuous flow meso reactors |
title_full | From discovery to production: Scale-out of continuous flow meso reactors |
title_fullStr | From discovery to production: Scale-out of continuous flow meso reactors |
title_full_unstemmed | From discovery to production: Scale-out of continuous flow meso reactors |
title_short | From discovery to production: Scale-out of continuous flow meso reactors |
title_sort | from discovery to production: scale-out of continuous flow meso reactors |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707018/ https://www.ncbi.nlm.nih.gov/pubmed/19590741 http://dx.doi.org/10.3762/bjoc.5.29 |
work_keys_str_mv | AT styringpeter fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors AT parrachoanair fromdiscoverytoproductionscaleoutofcontinuousflowmesoreactors |