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PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function

PPARδ (peroxisome proliferator-activated receptor δ) is a regulator of lipid metabolism and has been shown to induce fatty acid oxidation (FAO). PPARδ transgenic and knock-out mice indicate an involvement of PPARδ in regulating mitochondrial biogenesis and oxidative capacity; however, the precise me...

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Detalles Bibliográficos
Autores principales:	Kleiner, Sandra, Nguyen-Tran, Van, Baré, Olivia, Huang, Xueming, Spiegelman, Bruce, Wu, Zhidan
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Metabolism and Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707195/ https://www.ncbi.nlm.nih.gov/pubmed/19435887 http://dx.doi.org/10.1074/jbc.M109.008797

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