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Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study

STUDY OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) have low exercise capacity and low content of high energetic phosphates in their skeletal muscles. The aim of the present study was to investigate whether creatine supplementation together with exercise training may increas...

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Autores principales: Faager, Gun, Söderlund, Karin, Sköld, Carl Magnus, Rundgren, Siw, Tollbäck, Anna, Jakobsson, Per
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707812/
https://www.ncbi.nlm.nih.gov/pubmed/18044100
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author Faager, Gun
Söderlund, Karin
Sköld, Carl Magnus
Rundgren, Siw
Tollbäck, Anna
Jakobsson, Per
author_facet Faager, Gun
Söderlund, Karin
Sköld, Carl Magnus
Rundgren, Siw
Tollbäck, Anna
Jakobsson, Per
author_sort Faager, Gun
collection PubMed
description STUDY OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) have low exercise capacity and low content of high energetic phosphates in their skeletal muscles. The aim of the present study was to investigate whether creatine supplementation together with exercise training may increase physical performance compared with exercise training in patients with COPD. DESIGN: In a randomized, double-blind, placebo-controlled study, 23 patients with COPD (forced expiratory volume in one second [FEV(1)] < 70% of predicted) were randomized to oral creatine (n = 13) or placebo (n = 10) supplementation during an 8-week rehabilitation programme including exercise training. Physical performance was assessed by Endurance Shuttle Walking Test (ESWT), dyspnea and leg fatigue with Borg CR-10, quality of life with St George’s Respiratory Questionnaire (SGRQ). In addition, lung function test, artery blood gases, grip strength test, muscle strength and fatigue in knee extensors were measured. RESULTS: COPD patients receiving creatine supplementation increased their average walking time by 61% (ESWT) (p < 0.05) after the training period compared with 48% (p = 0.07) in the placebo group. Rated dyspnea directly after the ESWT decreased significantly from 7 to 5 (p < 0.05) in the creatine group. However, the difference between the groups was not statistically significant neither in walking time nor in rated dyspnea. Creatine supplementation did not increase the health related quality of life, lung function, artery blood gases, grip strength and knee extensor strength/fatigue. CONCLUSIONS: Oral creatine supplementation in combination with exercise training showed no significant improvement in physical performance, measured as ESWT, in patients with COPD compared with exercise training alone.
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spelling pubmed-27078122009-07-27 Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study Faager, Gun Söderlund, Karin Sköld, Carl Magnus Rundgren, Siw Tollbäck, Anna Jakobsson, Per Int J Chron Obstruct Pulmon Dis Original Research STUDY OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) have low exercise capacity and low content of high energetic phosphates in their skeletal muscles. The aim of the present study was to investigate whether creatine supplementation together with exercise training may increase physical performance compared with exercise training in patients with COPD. DESIGN: In a randomized, double-blind, placebo-controlled study, 23 patients with COPD (forced expiratory volume in one second [FEV(1)] < 70% of predicted) were randomized to oral creatine (n = 13) or placebo (n = 10) supplementation during an 8-week rehabilitation programme including exercise training. Physical performance was assessed by Endurance Shuttle Walking Test (ESWT), dyspnea and leg fatigue with Borg CR-10, quality of life with St George’s Respiratory Questionnaire (SGRQ). In addition, lung function test, artery blood gases, grip strength test, muscle strength and fatigue in knee extensors were measured. RESULTS: COPD patients receiving creatine supplementation increased their average walking time by 61% (ESWT) (p < 0.05) after the training period compared with 48% (p = 0.07) in the placebo group. Rated dyspnea directly after the ESWT decreased significantly from 7 to 5 (p < 0.05) in the creatine group. However, the difference between the groups was not statistically significant neither in walking time nor in rated dyspnea. Creatine supplementation did not increase the health related quality of life, lung function, artery blood gases, grip strength and knee extensor strength/fatigue. CONCLUSIONS: Oral creatine supplementation in combination with exercise training showed no significant improvement in physical performance, measured as ESWT, in patients with COPD compared with exercise training alone. Dove Medical Press 2006-12 2006-12 /pmc/articles/PMC2707812/ /pubmed/18044100 Text en © 2006 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Faager, Gun
Söderlund, Karin
Sköld, Carl Magnus
Rundgren, Siw
Tollbäck, Anna
Jakobsson, Per
Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title_full Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title_fullStr Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title_full_unstemmed Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title_short Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
title_sort creatine supplementation and physical training in patients with copd: a double blind, placebo-controlled study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707812/
https://www.ncbi.nlm.nih.gov/pubmed/18044100
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