P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

BACKGROUND: AVE9633 is a new immunoconjugate comprising a humanized monoclonal antibody, anti-CD33 antigen, linked through a disulfide bond to the maytansine derivative DM4, a cytotoxic agent and potent tubulin inhibitor. It is undergoing a phase I clinical trial. Chemoresistance to anti-mitotic age...

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Detalles Bibliográficos
Autores principales: Tang, Ruoping, Cohen, Simy, Perrot, Jean-Yves, Faussat, Anne-Marie, Zuany-Amorim, Claudia, Marjanovic, Zora, Morjani, Hamid, Fava, Fanny, Corre, Elise, Legrand, Ollivier, Marie, Jean-Pierre
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708190/
https://www.ncbi.nlm.nih.gov/pubmed/19549303
http://dx.doi.org/10.1186/1471-2407-9-199

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