Synergistic drug combinations improve therapeutic selectivity

Prevailing drug discovery approaches focus on compounds with molecular selectivity, inhibiting disease-relevant targets over others in vitro. However in vivo, many such agents are not therapeutically selective, either because of undesirable activity at effective doses or because the biological syste...

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Detalles Bibliográficos
Autores principales: Lehàr, Joseph, Krueger, Andrew S., Avery, William, Heilbut, Adrian M., Johansen, Lisa M., Price, E. Roydon, Rickles, Richard J., Short, Glenn F., Staunton, Jane E., Jin, Xiaowei, Lee, Margaret S., Zimmermann, Grant R., Borisy, Alexis A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708317/
https://www.ncbi.nlm.nih.gov/pubmed/19581876
http://dx.doi.org/10.1038/nbt.1549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708317/
https://www.ncbi.nlm.nih.gov/pubmed/19581876
http://dx.doi.org/10.1038/nbt.1549

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