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The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

The tumor suppressor p53 preserves genome integrity by inducing transcription of genes controlling growth arrest or apoptosis. Transcriptional activation involves nucleosomal perturbation by chromatin remodeling enzymes. Mammalian SWI/SNF remodeling complexes incorporate either BRG1 or Brm as the AT...

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Detalles Bibliográficos
Autores principales:	Naidu, Samisubbu R., Love, Ian M., Imbalzano, Anthony N., Grossman, Steven R., Androphy, Elliot J.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708319/ https://www.ncbi.nlm.nih.gov/pubmed/19448667 http://dx.doi.org/10.1038/onc.2009.121

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