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Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

The extent of bioactivation of the herbal constituent estragole to its ultimate carcinogenic metabolite 1′-sulfooxyestragole depends on the relative levels of bioactivation and detoxification pathways. The present study investigated the kinetics of the metabolic reactions of both estragole and its p...

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Detalles Bibliográficos
Autores principales:	Punt, Ans, Paini, Alicia, Boersma, Marelle G., Freidig, Andreas P., Delatour, Thierry, Scholz, Gabriele, Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M. C. M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Biotransformation and Toxicokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708596/ https://www.ncbi.nlm.nih.gov/pubmed/19447879 http://dx.doi.org/10.1093/toxsci/kfp102

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