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The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Kera...

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Autores principales: Gumus, Koray, Cavanagh, Dwight H
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709015/
https://www.ncbi.nlm.nih.gov/pubmed/19668545
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author Gumus, Koray
Cavanagh, Dwight H
author_facet Gumus, Koray
Cavanagh, Dwight H
author_sort Gumus, Koray
collection PubMed
description PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.
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spelling pubmed-27090152009-08-10 The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca Gumus, Koray Cavanagh, Dwight H Clin Ophthalmol Original Research PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS. Dove Medical Press 2009 2009-06-02 /pmc/articles/PMC2709015/ /pubmed/19668545 Text en © 2009 Gumus and Cavanagh publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Gumus, Koray
Cavanagh, Dwight H
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_full The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_fullStr The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_full_unstemmed The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_short The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_sort role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709015/
https://www.ncbi.nlm.nih.gov/pubmed/19668545
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