Cargando…
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Kera...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709015/ https://www.ncbi.nlm.nih.gov/pubmed/19668545 |
_version_ | 1782169261255426048 |
---|---|
author | Gumus, Koray Cavanagh, Dwight H |
author_facet | Gumus, Koray Cavanagh, Dwight H |
author_sort | Gumus, Koray |
collection | PubMed |
description | PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS. |
format | Text |
id | pubmed-2709015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-27090152009-08-10 The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca Gumus, Koray Cavanagh, Dwight H Clin Ophthalmol Original Research PURPOSE: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. METHODS: A comprehensive literature survey. RESULTS AND CONCLUSION: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS. Dove Medical Press 2009 2009-06-02 /pmc/articles/PMC2709015/ /pubmed/19668545 Text en © 2009 Gumus and Cavanagh publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Gumus, Koray Cavanagh, Dwight H The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title | The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title_full | The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title_fullStr | The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title_full_unstemmed | The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title_short | The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
title_sort | role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709015/ https://www.ncbi.nlm.nih.gov/pubmed/19668545 |
work_keys_str_mv | AT gumuskoray theroleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT cavanaghdwighth theroleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT gumuskoray roleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT cavanaghdwighth roleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca |