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Comparing 2-nt 3' overhangs against blunt-ended siRNAs: a systems biology based study

In this study, we formulate a computational reaction model following a chemical kinetic theory approach to predict the binding rate constant for the siRNA-RISC complex formation reaction. The model allowed us to study the potency difference between 2-nt 3' overhangs against blunt-ended siRNA mo...

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Detalles Bibliográficos
Autores principales:	Ghosh, Preetam, Dullea, Robert, Fischer, James E, Turi, Tom G, Sarver, Ronald W, Zhang, Chaoyang, Basu, Kalyan, Das, Sajal K, Poland, Bradley W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709260/ https://www.ncbi.nlm.nih.gov/pubmed/19594876 http://dx.doi.org/10.1186/1471-2164-10-S1-S17

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