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Energy profile and secondary structure impact shRNA efficacy
BACKGROUND: RNA interference (RNAi) is a cellular mechanism in which a short/small double stranded RNA induces the degradation of its sequence specific target mRNA, leading to specific gene silencing. Since its discovery, RNAi has become a powerful biological technique for gene function studies and...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709270/ https://www.ncbi.nlm.nih.gov/pubmed/19594886 http://dx.doi.org/10.1186/1471-2164-10-S1-S9 |