Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Transthyretin (TTR) is one of thirty non-homologous proteins whose misfolding, dissociation, aggregation, and deposition is linked to human amyloid diseases. Previous studies have identified that TTR amyloidogenesis can be inhibited through stabilization of the native tetramer state by small molecul...

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Detalles Bibliográficos
Autores principales: Palaninathan, Satheesh K., Mohamedmohaideen, Nilofar N., Orlandini, Elisabetta, Ortore, Gabriella, Nencetti, Susanna, Lapucci, Annalina, Rossello, Armando, Freundlich, Joel S., Sacchettini, James C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709434/
https://www.ncbi.nlm.nih.gov/pubmed/19621084
http://dx.doi.org/10.1371/journal.pone.0006290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709434/
https://www.ncbi.nlm.nih.gov/pubmed/19621084
http://dx.doi.org/10.1371/journal.pone.0006290

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